Iron-deficiency, Iron Deficiency Anemia
Conditions
Brief summary
Iron is a nutritionally essential mineral required for optimal physical and cognitive performance. Endurance exercise often leads to declines in iron status; however, the reason for the decline is not known. The primary objective of the proposed study is to determine the effects of an acute bout of strenuous endurance exercise on iron absorption and status and markers of inflammation in human volunteers. The investigators hypothesize that an acute bout of strenuous endurance exercise, compared to rest, will reduce iron absorption, resulting in diminished iron status, and that reduced iron absorption will be negatively associated with markers of inflammation. A secondary objective is to monitor iron status throughout a season of competition.
Interventions
OTHERMeal
Participants will consume a meal containing a stable iron isotope following exercise or rest.
Sponsors
Florida State University
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Members of the Florida State University Cross Country team * Refrain from using any pain-relievers (e.g., acetaminophen, nonsteroidal anti-inflammatory drugs such as aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product on the 2 study days * Refrain from using vitamin or mineral supplements on the study days
Exclusion criteria
* Musculoskeletal injury that compromise the ability to exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in fractional iron absorption | Red blood cells collected on day 0 and day 14 | Stable iron isotopes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in concentration of soluble transferrin receptor in nmol/L | Day 0 and day 14 | Blood measure |
| Change in concentration of hemoglobin in g/L | Day 0 and day 14 | Blood measure |
| Change in concentration of ferritin in ng/mL | Day 0 and day 14 | Blood measure |
| Change in concentration of hepcidin in ng/mL | Day 0 and day 14 | Blood measure |
| Change in concentration of IL-6 in pg/mL | Day 0 and day 14 | Blood measure |
| Change in concentration of hematocrit as % | Day 0 and day 14 | Blood measure |
Countries
United States
Outcome results
None listed