Autoimmune Thyroid Disease
Conditions
Keywords
Autoimmune thyroid disease, Thyroid hormone autoantibodies, Hashimoto's thyroiditis, Grave's disease
Brief summary
Thyroid hormone autoantibodies(THAA) in serum can Interfere radioimmunoassay for the determination of free thyroid hormones. Thyroid function test plays a key role in the diagnosis and treatment of autoimmune thyroid disease (AITD), and abnormal examination results in misdiagnosis and mistreatment. At present, the epidemiological results of THAA in AITD are inconsistent, and the pathogenesis has not been clarified. However, there is no relevant research on THAA in China. This project intends to collect AITD patients and healthy people, detecting THAA, at the same time testing thyroid function and thyroid autoantibodies, definiting positive rate of THAA in AITD patients, observing the effect of common therapeutic drugs for AITD on THAA, investigating the rule of THAA influencing thyroid function test results .This project will provide the basis and method for how to effectively avoid THAA interfering with thyroid function test.
Interventions
None listed
Sponsors
Shandong Provincial Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* male or female with Hashimoto thyroiditis or Grave's disease aged for 18 to 65 years old
Exclusion criteria
* Had a thyroidectomy Had a thyroid fine needle puncture biopsy Autoimmune diseases Take drugs that affect the immune system
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prevalence of thyroid hormone autoantibodies in AITD | measured after 1 year of follow-up | Radioimmuno precipitation test used for thyroid hormone autoantibodies |
Countries
China
Contacts
Primary ContactLing Gao
Outcome results
None listed