Colorectal Cancer
Conditions
Keywords
colorectal cancer, cohort study, CRC screening
Brief summary
NCRCC study is a national prospective cohort study including colorectal cancer screening population and stage Ⅰ-Ⅳ colorectal cancer patients.
Detailed description
NCRCC study is a large-scale multicenter study which includes 16 hospitals and research centers, establishing a national cohort which consists of two subcohorts (CRC Screening Cohort and Colorectal Cancer Patient Cohort). 1. To assess risk factors for colorectal cancer and evaluate risk prediction model of colorectal cancer to identify the high-risk population. 2. To discover, test and validate new biological markers (e.g. genetic, epigenetic, transcriptomic, metabolomics, proteomic and metagenomics biomarkers) for early diagnosis, prediction of clinical outcomes (e.g. therapeutic response, toxicity, surgical complications) and survivorship endpoints (e.g. recurrence, survival, quality of life, second primary cancer). 3. To estimate associations of epidemiological determinants (e.g. medication and supplement use, diet, lifestyle pattern) with clinical outcomes and survivorship endpoints among CRC patients.
Interventions
None listed
Sponsors
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
West China Hospital
Sun Yat-sen University
Shanghai Zhongshan Hospital
Peking University People's Hospital
Peking University Cancer Hospital & Institute
Fujian Cancer Hospital
Hubei Cancer Hospital
The First Affiliated Hospital with Nanjing Medical University
Shanxi Province Cancer Hospital
Changhai Hospital
Zhejiang Cancer Hospital
Third Affiliated Hospital of Third Military Medical University
Air Force Military Medical University, China
Sixth Affiliated Hospital, Sun Yat-sen University
Ding Ke-Feng
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Men and women * Mentally/physically able to consent and participate * Subjects aged ≥18 years old (Colorectal Cancer Patient Cohort, CRCPC), age 40-74 years (CRC Screening Cohort, CRCSC) * Newly-diagnosed colon and rectal cancer for stages Ⅰ-Ⅳ (CRCPC)
Exclusion criteria
* A history of colorectal cancer or bowel resection * Non-Chinese speaking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease-free and overall survival | up to 10 years |
| Recurrence/metastasis | up to 5 years |
| Adenoma or advanced adenoma incidence | up to 1 year |
| colorectal cancer incidence | up to 15 years |
Secondary
| Measure | Time frame |
|---|---|
| Prevalence of treatment-related toxicities characterized by the Common Toxicity Criteria for Adverse Events (CTCAE) | up to 5 years |
| Second primary cancer incidence | up to 15 years |
Countries
China
Contacts
Primary ContactKe-feng Ding, PhD/MD
Outcome results
None listed