Chronic Kidney Diseases, Lean Body Mass
Conditions
Keywords
mid-arm muscle circumference, handgrip strength, dual-energy x-ray absorptiometry
Brief summary
Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in non-dialyzed patients with chronic kidney disease (CKD). Objective: We developed and tested a reliable equations for estimation of LBM in daily clinical practice.
Detailed description
Two cross-sectional data sets were derived from outpatients with CKD stage 3-5 in Peking University First Hospital.Two equations for estimating LBM based on midarm muscle circumference (MAMC) or hand grip strength (HGS)were developed and validated in CKD patients with dual-energy x-ray absorptiometry (DEXA) as referenced gold method. Demographic data, comorbidity, and other clinical variables were also recorded.
Interventions
None listed
Sponsors
Peking University First Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* non-dialyzed patients with CKD stage 3-5 * clinical stable * a willingness to be examined with all measurements being taken simultaneously.
Exclusion criteria
* systemic infections, acute cardiovascular events, operations, trauma, active hepatitis or tumor * severe edema within one month prior to the study * chronic infections, connective tissue disease, hyper- or hypothyroidism, amputations or pregnancy, * taking immunosuppressive agents and anti-inflammatory medication chronically
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| LBM_DEXA | between March 1st, 2014 and December 1st, 2015 | lean body mass measured by dual-energy x-ray absorptiometry (DEXA) |
Countries
China
Outcome results
None listed