Kidney Stones, Urolithiasis, Hypocitraturia
Conditions
Keywords
Kidney Stones, Urolithiasis, Hypocitraturia, Apple Cider Vinegar
Brief summary
The purpose of this study is to assess whether certain beverages can increase urinary citrate levels in healthy individuals with no history of kidney disease.
Detailed description
Higher urinary citrate levels have been shown to decrease one's risk of developing kidney stones. The study will compare apple cider vinegar, coconut water, diet citric soda and lemonade and determine which is superior at raising citrate levels. Research participants will consume two of the four drinks, each for 7 day periods, according to a prescribed regimen. Throughout the course of the study, participants will periodically provide blood draws for metabolic panels, as well as 24-hour urine samples to measure citrate levels. There will be 12 study arms, accounting for the permutations of two drinks for each patients out of four possibilities. 3 participants per arm is the goal, for a total of 36, but the recruitment aim is 50 participants, to account for dropout and noncompliance.
Interventions
DIETARY_SUPPLEMENTApple Cider Vinegar
Will drinking apple cider vinegar increase urinary citrate levels to a greater degree than other beverages and which beverages produce the most significant effects compared against one another.
DIETARY_SUPPLEMENTOther Beverage
To what degree do other high citrate beverages impact urinary citrate output.
Sponsors
United States Naval Medical Center, San Diego
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Prospective randomized sample of 36 patients, in a nested cross over design.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and female volunteers 18-65 years old
Exclusion criteria
* History of peptic ulcer disease or gastroparesis * Pregnant females * History of chronic kidney disease * History of urolithiasis * Currently taking medications that interfere with urinary electrolyte excretion (thiazide and loop diuretics)javascript:document. * History of Diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Apple Cider Vinegar Urinary Citrate Increase | 1 week | Determine the change in urinary citrate levels due to the addition of apple cider vinegar to the diet |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Apple Cider Vinegar and urinary pH | 1 week | Determine the effect of apple cider vinegar on urinary pH |
| Apple Cider Vinegar Against Other Beverages | 4 weeks | Compare the effect of apple cider vinegar on urinary citrate with that of known citrate-rich beverages (lemonade, citrus based soda, coconut water) |
| Palatability Evaluation | 4 weeks | Compare the palatability of apple cider vinegar and other known citrate-rich beverages (lemonade, citrus based soda, coconut water). Patients will keep daily log whwere they can free write any side effects (from palatability perspective and otherwise). At the end of the study a 2 question survery (Likert scale format) will be filled in which participants will answer the liklihood of their willingness to consume the beverage daily for the prevention of kidney stones. |
Contacts
Primary ContactChristine M Herfroth, MD
Backup ContactJesse E Resovsky, BS
Outcome results
None listed