Thyroid Cancer
Conditions
Keywords
thyroid cancer, SREBP1
Brief summary
In this study, the investigators detected the expression of SREBP1 in thyroid cancer tissues, explored the biological functions of SREBP1 in thyroid cancer cells.
Detailed description
qRT-PCR and immunohistochemistry were used to detect the expression of SREBP1 in 96 pairs thyroid cancer tissues and the adjacent normal tissues. The following methods, including the MTS, colony-forming assay, flow cytometry and hoechst staining were used to detect the biological function of thyroid cancer cells based on SREBP1 interference or not.
Interventions
OTHERpathologic
All the enrolled patients were treated with whole resection and diagnosed by the Pathology Department based on the pathological evidence.
Sponsors
People's Hospital of Zhengzhou University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Clinical diagnosis of thyroid cancer Reciving thyroidectomy surgery No experience of radiation therapy Nice treatment compliance and follow-up regularly
Exclusion criteria
Prior history of malignancy ; Radiotherapy history, chemotherapy history; Serious concomitant diseases ; Chronic renal insufficiency and liver dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| progression-free survival | average 5 years | disease recurrent of progression |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| theraputic efficacy | average 18 months | According to the ATA guideline, patients were divided into four group, including excellent response (ER),indeterminate response (IDR), biochemical incomplete response (BIR), structural incomplete response (SIR) after surgery and radioiodine treatment. |
Countries
China
Outcome results
None listed