Colorectal Cancer
Conditions
Keywords
Microbiota
Brief summary
This is a prospective study evaluating the relation between the gut microbiota composition, intestinal healing after colorectal surgery and colorectal cancer behavior. Our hypothesis is that the gut microbiota composition could predict poor intestinal healing in colorectal surgery, and that the gut microbiota might have an impact on colorectal cancer clinical behavior and may predict disease outcomes.
Detailed description
No more details required
Interventions
None listed
Sponsors
Centre hospitalier de l'Université de Montréal (CHUM)
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 years and older * CRC diagnosis * Upcoming colonic and/or rectal resection with/without anastomosis * Individuals without diseases of the colon and rectum (healthy controls)
Exclusion criteria
* Pregnancy * Previous stoma * Bowel surgery in the last 4 weeks prior to the surgery Secondary objectives, inclusion criteria are as follows: * Age 18 years and older * Rectal cancer diagnosis with histopathological confirmation * Abdominoperineal resection with terminal colostomy * Expectative non-surgical management (Watch and wait approach)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with an anastomotic leak | 1 month | Clinical and/or radiological anastomotic leak |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with cancer reoccurence | 3 years | Colorectal cancer local or distant reoccurence |
Countries
Canada
Outcome results
None listed