MDD
Conditions
Keywords
eye-tracking, eye movement, mindfulness
Brief summary
The purpose of this study is to investigate the short-term effects of mindfulness-based training in individuals suffering from major depressive disorder (MDD) as assessed by clinical interviewing, self-report assessment, cognitive evaluation and eye-tracking task.
Interventions
BEHAVIORALMindfulness-Based Training
Mindfulness-Based Training comprises of mindful walking, body scanning and raisin meditation exercise. Participants will receive a guided session of mindfulness meditation, and will be asked to finish at least 30 minutes of Mindfulness-Based Training every day as homework as well as keep a diary describing their experiences and reflections. An expert in mindfulness practice will offer feedback and answer any questions online.
BEHAVIORALRelaxation Training
Participants will listen to a 15-minute Relaxation Training tape twice a day.
Sponsors
Central South University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Meet Diagnostic and Statistical Manual (DSM-IV) diagnosis of depression * Consent to participate in the study and to be randomized to one of two groups
Exclusion criteria
* Current or past substance abuse, psychotic disorder,obsessive compulsive disorder , Post-Traumatic Stress Disorder, in the past 6 months * History of epilepsy or head trauma * Eye disorders * History of electroconvulsive therapy in the past 4 weeks.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean Change from Baseline in Eye Movement Performance During Free-View Task at 2 Weeks | at baseline and in 2 weeks | The first fixated location and latency (msec) of each trial, the total dwell time (msec) in each interest area (IA) during the whole trial to assess the attentional bias in the experiment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean Change from Baseline in the Symptoms of Major Depression as Measured by BDI-II at 2 Weeks | at baseline and in 2 weeks | Measured by Beck Depression Inventory (BDI-II). BDI-II is a self-report questionnaire that measures the severity of depression on a scale of 0 to 63. Higher total scores indicate more severe depressive symptoms. |
| Mean Change from Baseline in the Symptoms of Major Depression as Measured by HAM-D at 2 Weeks | at baseline and in 2 weeks | Measured by Hamilton Rating Scale for Depression (HAM-D). HAM-D is used by clinicians to rate the severity of depression and to evaluate recovery. HAM-D score ranges from 0 to 51, with higher scores indicating more severe depressive symptoms. |
| Mean Change from Baseline in State Mindfulness at 2 Weeks | at baseline and in 2 weeks | Measured by the Five Facet Mindfulness Questionnaire (FFMQ). FFMQ measures five mindfulness skills through these subscales: Non-Reactivity to Inner Experience, Observing/Noticing, Acting With Awareness, Describing, and Non-Judging of Experience. The five subscale scores can be combined to yield a total score ranging from 0 to 195, measuring global mindfulness skills, with higher scores indicating higher level of global mindfulness skills. For FFMQ subscales, scores range from 8 to 40, except for Non-Reactivity to Experience scores, which range from 7 to 35. Higher subscale scores indicate higher level of respective mindfulness skills. |
| Mean Change from Baseline in Tendency to Engage in Ruminative Responses at 2 Weeks | at baseline and in 2 weeks | Measured by the Ruminative Responses Scale of the Response Styles Questionnaire (RRS). RRS measures the tendency to ruminate. RRS score ranges from 22 to 88, with higher scores indicate a stronger tendency to engage in ruminative thoughts. |
Countries
China
Contacts
Primary ContactLi Lingjiang, MD Ph.D
Outcome results
None listed