Observation of Blood Orphanin and Norepinephrine Levels in Diabetic Patients Under Subarachnoid Anesthesia

Effect of Subarachnoid Anesthesia on Blood Orphanin and Norepinephrine in Diabetic Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04071834

Enrollment

120

Registered

2019-08-28

Start date

2019-10-01

Completion date

2020-06-01

Last updated

2020-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraspinal Anesthesia

Brief summary

This study aims to investigate the Influence of Intraspinal anesthesia to the concentrations of blood orphanin, norepinephrine in patients with diabetes mellitus. We hope to explain the relationship between sensory and sympathetic nerves in diabetic patients undergoing intraspinal anesthesia.

Interventions

DIAGNOSTIC_TESTELISA

Detection of blood orphanin and norepinephrine in patients

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing lower limb surgery under spinal anesthesia

Exclusion criteria

* Emergency surgery * The operation time is more than 3 hours * Combined general anesthesia or nerve block anesthesia

Design outcomes

Primary

Measure	Time frame	Description
Blood orphanin concentration	24 hours	Concentration of blood orphanin in patients before and after anesthesia
Blood norepinephrine concentration	24 hours	Concentration of blood norepinephrine in patients before and after anesthesia

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026