Using Sensors to Measure Drug Concentrations in Exhaled Breath

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04071145

Enrollment

100

Registered

2019-08-28

Start date

2019-09-30

Completion date

2020-10-31

Last updated

2019-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental Disorder

Brief summary

The use of blood tests to measure drug concentrations in psychiatric patients is often a crucial part of monitoring and evaluating the course of treatment. Such tests are commonly conducted as part of official protocols, and patients are often tested on a weekly basis. The current study aims to examine the possibility of using a novel, non-invasive device to measure drug concentrations in exhaled breath as an alternative to blood tests. The device, SniffPhone, uses sensors to detect and measure volatile organic compounds (VOCs) in exhaled breath, and features a small and portable design. Sniff Phone has been previously approved for use in clinical trials and has been used successfully to screen for particular types of cancer and other diseases.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* Proper ability to give informed consent * Psychiatric patients undergoing treatment at Sheba Medical Center * Patients with treatment plans that require therapeutic drug monitoring

Exclusion criteria

* Involuntary psychiatric hospitalization * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Detection of drug type and concentration in volatile organic compounds (VOCs) profile	Up to 6 months	Detection of drug type and concentration in VOCs profile (measured using Sniff Phone)
Correlation between drug concentration and volatile organic compounds VOC concentrations	Up to 6 months	Correlation between drug concentration (as measured in blood test) and VOCs (hexanone acetic acid, heptane, hexanal, 3-heptanone, hexanoic acid, heptanal and nonanal) measured using Sniff Phone.

Outcome results