Post Traumatic Stress Disorder
Conditions
Brief summary
A psychiatric diagnosis of post-traumatic stress disorder (PTSD) is currently based mainly on non-quantitative elements, such as interviews and subjective impressions. PTSD has physiological manifestations, some of which are likely reflected in the levels and ratios of certain stress-related proteins in the interstitial fluid and plasma. Discernable patterns of such stress-related proteins may constitute a biochemical phenotype characteristic of PTSD, which may serve as a biomarker and support diagnostic decisions, as well as personalized treatment plans. The current study is a non-interventional observational study aimed at examining the possibility of basing a psychiatric diagnosis by measuring changes in the biochemical phenotype of participants with PTSD.
Interventions
None listed
Sponsors
Nadav Goldental
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* PTSD diagnosis (excluding controls) * Proper ability to give informed consent
Exclusion criteria
* Active psychotic or suicidal symptoms * Active/terminal oncological condition * Dialysis patients * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in c-reactive protein (CRP) | 3 months | Changes in c-reactive protein (CRP) levels as measured by the adhesive biosensor patches |
| Changes in Interleukin 6 (IL-6) levels | 3 months | Changes in Interleukin 6 (IL-6) levels as measured by the adhesive biosensor patches |
| Changes in cortisol levels | 3 months | Changes in cortisol levels as measured by the adhesive biosensor patches |
| Changes in N-terminal pro b-type Natriuretic Peptide (NT-proBNP) levels | 3 months | Changes in N-terminal pro b-type Natriuretic Peptide (NT-proBNP) levels as measured by the adhesive biosensor patches |
| Changes in 8-Oxo-2'-deoxyguanosine (8-oxo-dg) levels | 3 months | Changes in 8-Oxo-2'-deoxyguanosine (8-oxo-dg) levels as measured by the adhesive biosensor patches |
| Changes in volatile organic compounds (VOCs) levels | 3 months | Changes in volatile organic compounds (VOCs) concentrations (hexanone, acetic acid, heptane, hexanal, 3-heptanone, hexanoic acid, heptanal and nonanal) as measured by the adhesive biosensor patches |
| Changes in glucose levels | 3 months | Changes in glucose levels as measured by the adhesive biosensor patches |
| Correlations between biochemical changes and PTSD clinical symptoms | 3 months | Correlations between biochemical changes and questionnaire data relating to PTSD clinical symptoms (CGI, CAPS, PHQ, PCL-5, PC-PTSD-5, LEC-5 and BARS). |
Outcome results
None listed