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Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy

Comparative Evaluation of Local Injectable Platelet Rich Fibrin and Hyaluronic Acid as Adjunctive to Non Surgical Periodontal Therapy: a Randomized Placebo Controlled Clinical Trial

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04070729
Enrollment
120
Registered
2019-08-28
Start date
2019-08-28
Completion date
2020-01-25
Last updated
2019-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CHRONIC PERIODONTITIS

Brief summary

Clinical evaluation of local subgingival application of injectable platelet-rich fibrin ( i-PRF ) for chronic periodntitis as adjunctive to non surgical therapy and compare it with hyaluronic acid. 120 periodontal patients will receive a scaling and root planing ( non surgical periodontal therapy). Equal number of patients will receive subgingival application of i-PRF, hyaluronic acid or placebo gel as the adjunction to non surgical therapy.

Detailed description

The aim of the study is to evaluate and compare the clinical efficacy of subgingival application of i-PRF and hyaluronic acid gel as adjunctive to non-surgical periodontal therapy. 120 periodontal patients will receive traditional mechanical supra and subgingival scaling and root planing. Patients were randomly allocated in three groups. Group 1, 2 and 3 will receive subginigval application of placebo, hyaluronic acid gel and i prf respectively. Clinical parameters will be evaluated: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), gingival recession (GR). Clinical measurements will be performed at baseline, 1 month and at 3 months.

Interventions

DRUGHyaluronic acid gel

Localized subgingival application

BIOLOGICALPlatelet rich fibrin

Localized subgingival application

OTHERPlacebo gel

Localized subgingival application

Sponsors

Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
30 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* Patients are in general good health. * Patients having minimum of 20 permanent teeth. * They have not taken medication known to interfere with periodontal tissue health or healing in the preceding 6 months. * Presence of periodontal pockets (≥5 mm) and clinicala ttachment level \> 5 mm.

Exclusion criteria

* Immunosuppressive systemic diseases (like cancer, AIDS, diabetes etc.) * Clotting and Hematological disorders * Patients with grade III mobility. * Patients with smoking and alcohol consuming habit. * Pregnant and lactating female. * Medications influence on the gingival and periodontal tissues (like calcium channel blockers, or Long-term steroid use) * The teeth with poor filling and ill fitted restorations

Design outcomes

Primary

MeasureTime frameDescription
Clinical attachment level (CAL)3 MonthsMeasure as the change in distance from the cementoenamel junction to the bottom of the gingival sulcus by using a periodontal probe (UNC 15 University of North Carolina)

Secondary

MeasureTime frameDescription
Probing pocket depth3 MonthsMeasure as the change in distance from the gingival margin GM to the bottom of the gingival sulcus by using a periodontal probe (UNC 15 University of North Carolina)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026