Laser Therapy on Orthodontic Tooth Movement

The Effects of Lower Level Laser Therapy on Orthodontic Tooth Movement

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04070170

Enrollment

Registered

2019-08-28

Start date

2014-02-01

Completion date

2019-09-16

Last updated

2020-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Remodeling, Laser Therapy, Orthodontic Tooth Movement

Keywords

Low-Level Light Therapy, Tooth Movement, Bone Remodeling

Brief summary

The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.

Interventions

DEVICELow-level Laser Therapy

Low-level laser therapy is applied on premolars that will be extracted for treatment plan reasons

PROCEDUREOrthodontic force

Mechanical loading is applied on premolars that will be extracted for treatment plan reasons and in canines for tooth movement

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

13 Years to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* Facial convexity * Protrusion or biprotrusion of the incisors * Dental crowding * Healthy periodontal condition * Satisfactory oral hygiene

Exclusion criteria

* Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months * Skeletal crossbite * Parafunctional habits * Occlusal interference

Design outcomes

Primary

Measure	Time frame	Description
Rate of orthodontic tooth movement, with and without low-level laser therapy	The quantification of OTM was performed before canine retraction	The canine retraction was measured with a digital dynamometer

Secondary

Measure	Time frame	Description
Chemokine levels in the periodontal tissue after LLLT and orthodontic force	The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy	The chemokine levels were measured in the periodontal tissue after LLLT and orthodontic force by means of a cytometric bead array (CBA)

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026