Autism Spectrum Disorder
Conditions
Keywords
Autism Spectrum Condition, predictive coding, visual perception, electroencephalography, autonomous nervous system, heart rate variability, electrodermal reactivity
Brief summary
This project aims: * to study behavioral and cerebral activity specificity (latency and amplitude of evoked potentials, time frequency maps and cerebral connectivity) in predictive process (top-down regulation) during visual recognition of static and dynamic stimuli in adults participants with autism spectrum conditions compared to typically developed participants. * to study the relation between predictive process and autonomous response (heart activity and electrodermal activity) * to explore potential sex differences between autistic males and females
Detailed description
Once eligibility criteria would have been verified, information on the study will be given and non opposition of the participant will be collected.Then, the participant will be comfortably installed in order to pass the Landolt C task (visual acuity task) on a computer. If his vision is normal, electroencephalogram (EEG), electrocardiogram (ECG) and electrodermal activity (EDA) of participants, will be recorded during visual processing and recognition tasks. Stimuli will include emotional and non emotional pictures and films, filtered in coarse-to-fine versus fine-to-coarse sequences in order to stimulate or not predictive process described by Bar (2007). The participant will also have to complete an abbreviated version of the Wechsler Adult Intelligence Scale, IVth edition (Wechsler, 2003), and the Autism Spectrum Quotient (Baron-Cohen et al., 2001) if he never did it before. The aim is to pair as much as possible group by IQ and to verify that control participants don't present autistic traits above the Autism Spectrum Quotient cutoff. Groups will also be paired by age and education level.
Interventions
OTHEREEG
EEG, ECG and EDR record during a behavioral task
Sponsors
Laboratoire de Psychologie et NeuroCognition
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* affiliation to the french social protection care * information and non opposition of the participant * information and non opposition of tutor/curator if the case presented * normal or corrected to normal vision * capacity to understand and apply instruction required by the task * no participation in another research * for autistic person: formal diagnosis of autism spectrum condition (autism/asperger/PDD-NS) according to CIM-10/DSM-IV/DSM-5 criteria
Exclusion criteria
* adults with no ability to express their consent * adults on judiciary protection * perceptive/motor/neurological/psychiatric issue * major health issue (cardiac, metabolic ...) * alcohol or drug consumption
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences between autistic and typically developed participants in evoked potentials related to prediction mechanisms during visual processing | 55 minutes recording | \- differences in evoked potentials (latency and amplitude) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding cerebral activity. |
| Differences between autistic and typically developed participants in behavioral responses related to prediction mechanisms during visual processing | 55 minutes (same recording as before) | \- differences in behavioral responses (reaction time and correct response rate) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding behavioral response. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Differences between groups in oscillatory activity | 55 minutes (same record as before) | -differences in time-frequency maps. Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding cerebral activity. |
| Difference between groups in cerebral connectivity | 55 minutes (same record as before) | \- differences in Dynamic Causal Modeling Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding cerebral activity. |
| Differences between groups in autonomous activity | 55 minutes (same record as before) | * ECG activity (HRV analysis) * electrodermal activity (EDA) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding autonomous activity. |
| Sex differences | 55 minutes (same record as before) | \- sex differences analysis Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated the existence of sex differences in autism regarding predictive process during visual perception. |
Countries
France
Outcome results
None listed