Lung; Premature, Pollution; Exposure
Conditions
Keywords
Atmospheric particles
Brief summary
The objective of this study is to evaluate the transplacental passage of fine and ultrafine particles (nanoparticles) inhaled by the mother.
Detailed description
Epidemiological studies have demonstrated the harmful effects of particulate air pollution on the progress of pregnancy and postnatal health. Experimental studies have suggested the transplacental passage of asbestos fibers, but despite the strong growth in the use and production of fine and ultrafine particles, no study has examined the permeability of the placenta to these compounds or the exposures fetuses that may result. The objective of this study is to evaluate the transplacental passage of fine and ultrafine particles (nanoparticles) inhaled by the mother.
Interventions
PROCEDUREPulmonary Tissue Collection
Pulmonary Tissue Collection
Sponsors
University Hospital, Bordeaux
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Inclusion criteria
\- All women volunteers for whom a medical termination of pregnancy is proposed for a fetus older than 22 weeks (weight over 500g).
Exclusion criteria
* Refusal of participation of the patient. * Fetus with malformation syndrome affecting pulmonary perfusion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of fine particles in fetal lung samples yes/no | At the screening | Analysis in electron microscopy |
Contacts
PRINCIPAL_INVESTIGATOROlivia OCHRYMCZUK, Dr
University Hospital, Bordeaux
Outcome results
None listed