Myocardial Ischemia
Conditions
Brief summary
The investigators goal is to determine whether cardiopulmonary exercise testing (CPET) can be utilized in the diagnosis of myocardial ischemia. For the study participants the investigators will recruit patients who have been referred to myocardial perfusion PET/CT scan in Kuopio University Hospital. The participants will perform the CPET on a cycle ergometer on separate day after the perfusion scan. The investigators will compare the results of the PET/CT scan and CPET and evaluate if the possible perfusion defects detected in PET/CT correlate with the gas exchange parameters in CPET. The patients who receive invasive coronary treatment (coronary bypass surgery or percutaneous coronary intervention) will be invited to perform additional CPET ja PET/CT tests six months after the treatment. The goal will be to determine whether the recovery of myocardial perfusion can be assessed with gas exchange parameters in CPET.
Interventions
PROCEDUREInvasive coronary treatment
Coronary artery bypass surgery or percutaneous coronary intervention.
Sponsors
Kuopio University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Patients who receive invasive coronary treatment will undergo additional coronary perfusion PET/CT and CPET tests six months after the treatment.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Referral to coronary perfusion PET/CT scan in Kuopio University Hospital
Exclusion criteria
* Age under 18 years * Pregnancy or breastfeeding * Handicap * Imprisonment * Care under forensic psychiatry
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of myocardial ischemia assessed by the myocardial perfusion positron emission tomography | 6 months | Regional myocardial perfusion below 2.3 ml/g/min measured by the quantitative positron emission tomography is a marker of myocardial ischemia |
| Presence of myocardial ischemia assessed by the cardiopulmanary exercise test | 6 months | Criteria for myocardial ischemia that must be fulfilled are 1) Double sloping in the oxygen consumption/work rate trajectory, peak oxygen consumption below limit of the lowest normal, and abnormal oxygen pulse trajectory during the cardiopulmonary exercise test. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Agreement in the detected myocardial ischemia between the myocardial perfusion positron emission tomography and the cardiopulmonary exercise testing | 6 months | Positron emission tomography is the golden standard in the detection of myocardial ischemia. Results of cardiopulmary exercise testing will be compared with those of positron emission tomography using ROC-analysis. 6 months follow-up enables evaluation of reversibility of changes. |
Countries
Finland
Contacts
Primary ContactTomi Laitinen
Outcome results
None listed