ARDS
Conditions
Brief summary
The study aims to investigate the association between effects of PEEP on gas exchange model parameters and CT scan results
Detailed description
In ARDS patients on mechanical ventilation, we will compare model-based estimation of gas exchange parameters (shunt, ventilation/perfusion mismatch) with CT-based estimation of effects of low and high PEEP
Interventions
DIAGNOSTIC_TESTALPE
Measurement of CT scan at PEEP of 5, 20 and 45 cm H2O Measurement of gas exchange by model-based method and FiO2 titration at PEEP of 5 and 20 cm H2O
Sponsors
Policlinico Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- ARDS patients requiring mechanical ventilation
Exclusion criteria
* \<18 years old * Requirement of extracorporal life support * Hemodynamic instability * Barotrauma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gas Exchange and lung recruitability at diferent PEEP levels | Approximately two hours | Gas exchange (At PEEP 5 and 20 cm H2O), CT scan (At PEEP 5, 20 and 45 cm H2O) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physiologic Parameter 1 | Approximately two hours | Hemodynamic assessment at different PEEP levels |
| Physiologic Parameter 2 | Approximately two hours | Respiratory mechanics at different PEEP levels |
Countries
Italy
Outcome results
None listed