Alleviating Effects Against Dry Eye by Oral Intake of Cordyceps Cicadae Mycelia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04063735

Enrollment

Registered

2019-08-21

Start date

2016-12-01

Completion date

2017-11-30

Last updated

2019-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Eye, Supplement

Keywords

Dry Eye, Cordyceps cicadae mycelia

Brief summary

Cordyceps cicadae mycelia was tested for amelioration of dry eye symptoms through dietary supplementation. Its efficacy in relief of human dry eye status was assessed by randomized, double-blinded tests, including multiple assessments. The results were compared between the placebo group and the experimental group.

Detailed description

Former animal studies had shown that Cordyceps cicadae mycelia can effectively ameliorate UVB-induced dry eye symptoms. This study further investigated its efficacy in human dry eye status by randomized, double-blinded tests, including dry eye questionnaires, blood tests, salivary tests, tear volume test, intra-ocular pressure assessments, ocular surface photography, corneal fluorescein stain, tear film breakup time test, fundus photography, and cornea impression cytology. All tests were performed again after 3 months of dietary supplement of either samples or placebo. A total of 97 participants completed the trial. The data were analyzed by paired-t test and compared between the placebo and the experimental groups.

Interventions

DIETARY_SUPPLEMENTCordyceps Cicadae Mycelia

Cordyceps Cicadae Mycelia supplement for 3 months

DIETARY_SUPPLEMENTPlacebo

Placebo was given to participants.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Intervention model description

Randomized double-blinded placebo study

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Adults aged from 20 to 60 with dry eye symptoms confirmed by ophthalmologists, and without chronic diseases.

Exclusion criteria

* Those vulnerable to damages or loss of self-conscious, or behavior capacity, or with major illness or with critical diseases.

Design outcomes

Primary

Measure	Time frame	Description
tear film breakup time	day 1 to day 90.	Tear film breakup time was used for tear quality assessments.
Cornea surface scores based on Efron grading system	day 1 to day 90.	Cornea surface scores based on Efron grading system was used for assessment of cornea surface damages.
Intra-ocular pressure	day 1 to day 90.	Intra-ocular pressure was taken to assess eye pressure.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026