End Stage Renal Disease, Hemodialysis Complication, Kidney Diseases
Conditions
Keywords
clotting, coagulation
Brief summary
Every patient included in the study will undergo 1 conventional hemodialysis treatment, ie 1 study visit. During the conventional hemodialysis treatment lasting 4 hours, 2 blood samples will be taken at different time points (5 minutes after dialysis start and 240 minutes after dialysis = at the end of the dialysis session) to evaluate coagulation activation (TAT, PF1+2). Hemodialysis session parameters (arterial and venous pressure, TMP, OCM, BVM and prefilter pressure) will be noted at different time points (T5, T30, T60, T120, T180, T240). After discontinuation of the dialysis session, total cell volume will be measured using the Renatron II system® and the number of open fibers will be determined using micro-CT scanning.
Interventions
PROCEDUREblood sample
Blood sample at start and at the end of the dialysis session; membrane scoring after dialysis; total cell volume measurement of dialyzer after dialysis; micro-CT of dialyzer after dialysis.
Sponsors
Universitair Ziekenhuis Brussel
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ≥ 18 years of age. * Patients able and agree to provide signed informed consent.
Exclusion criteria
* Known allergy for polysulphone dialysis membrane. * Use of vitamin K antagonists or novel oral anticoagulant therapy. * Use of chronic heparin treatment, UFH or LMWH.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| TAT | From first hemodialysis study session until interpretation of biological results, up to 6 months | thrombin antithrombin complex levels (mcg/L). Samples for TAT measurement were taken during the single hemodialysis study treatment. All patients underwent their study treatments between October - December 2018. All analyses were performed in batch in January 2019. |
| open fibers | From first hemodialysis study session until interpretation of scan results, up to 6 months | number of open fibers of dialyzer counted after microCT scanning of dialyzer membrane. Dialyzers were collected after the hemodialysis study treatment. All patients underwent their study treatments between October - December 2018. All micro CT scans were performed using the same scanner in Fabruary and March 2019. |
Countries
Belgium
Outcome results
None listed