Diet, Healthy, Healthy Aging, Metabolic Syndrome
Conditions
Brief summary
The overall aim of the present research program is to determine how a healthy whole-diet approach impacts on cardiometabolic health in adults. With its interdisciplinary approach, the study depicts mechanisms behind disease progression and the impact of healthy dietary patterns on changes in markers of low-grade systemic inflammation together with the exploration of knowledge and attitudes about healthy diets. The study has a preventive character as it targets older adults (65+) without manifest disease.
Detailed description
This two arm randomized-controlled study includes the following groups: Controls and Healthy Diet group. The study will particularly address the following aspects: * determine food literacy, perceived attitudes and barriers for the adoption of new dietary habits incorporating increased fruit and vegetable intake in adults. * explore the effects of a randomized controlled intervention promoting healthy dietary patterns (increased intakes of fruit and vegetable, whole-grain, nuts and low fat dairy products and replacing saturated with unsaturated fats and decreased red meat and salt consumption) for a period of 4 months on components of the metabolic syndrome, a large panel of pro- and anti-inflammatory biomarkers and metabolomic profile in adults. * assess the long-term adherence to healthy dietary patterns in adults. * provide support for behavioural change and evaluate participants' perception of this support.
Interventions
BEHAVIORALHealthy Diet
Receive counseling to meet guidelines for healthy dietary patterns
Sponsors
Horizon 2020 - European Commission
Örebro University, Sweden
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* 65-70 years * not meeting 5 servings of fruit and vegetable per day * Waist circumference \>80 cm (female) and \>88 (male)
Exclusion criteria
* Movement disability * Diabetes, cardiovascular disease, lung disease, overt disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in blood glucose | Before and after 16 weeks | Blood glucose (mmol/L) assessed using chemistry kits from Ortho-Clinical Diagnostics on a Vitros-5.1 analyzer platform (Clinical Diagnostics, Raritan, NJ, United States) |
| Change in plasma triglycerides | Before and after 16 weeks | Plasma triglycerides (mmol/L) : assessed using chemistry kits from Ortho-Clinical Diagnostics on a Vitros-5.1 analyzer platform (Clinical Diagnostics, Raritan, NJ, United States) |
| Change in high-density lipoprotein cholesterol | Before and after 16 weeks | high-density lipoprotein cholesterol (mmol/L) : assessed using chemistry kits from Ortho-Clinical Diagnostics on a Vitros-5.1 analyzer platform (Clinical Diagnostics, Raritan, NJ, United States) |
| Change in waist circumference | Before and after 16 weeks | waist circumference (cm) assessed by a steel tape |
| Change in diastolic and systolic blood pressure (mmHg) | Before and after 16 weeks | diastolic and systolic blood pressure (mmHg) assessed using a manual sphygmomanometer |
| Change in intake of fruit and vegetable | Before and after 16 weeks | \- Fruit and vegetable intake assessed on a 7 scale-item where the lowest value of 1, indicates an intake less than 1 per month, and 7 an intake of at least 5 servings /day. |
Countries
Sweden
Outcome results
None listed