Healthy Volunteer, Parkinson Disease
Conditions
Brief summary
The research study is being conducted to test how a specialized type of Positron Emission Tomography (PET/CT) scan could potentially be useful in diagnosing or monitoring treatment in people with Parkinson's disease. If the subject decide to be in this study he/she will have a PET/CT scans using an imaging drug called 18F-NOS which will be used to measure inflammation in the brain.
Detailed description
The purpose of this research is to test whether it is possible to measure inflammation in subject's brain using an imaging scan called Positron Emission Tomography / Computed Tomography (PET/CT). There are two groups of people who will participate in this study, a Parkinson's disease (PD) group and a Control group Both groups will have imaging with a radioactive drug called 18F-NOS which is an experimental radioactive drug used in PET/CT imaging to measure inflammation in the brain. 18F-NOS has not yet been approved by the Food and Drug Administration (FDA) for use except in a research study. The use 18F-NOS in this study is allowed under an Investigational New Drug Application approved by the FDA. If subject agree to participate in this study, she/ he will undergo one experimental 18F-NOS PET/CT scan. During the scan, PET/CT images will be taken of subject head in order to capture pictures of their brain. The imaging procedures will be explained to subject in more detail below. Blood samples will be taken at various time points to measure the concentration of the imaging drug in your blood during the scan and a blood sample will be collected to measure specialized inflammation markers in the blood. Investigator hopes to compare the PET/CT scans for the two groups to see if there are differences between Parkinson patients and Controls. Investigator will also compare the results with other informationgathered about subject during their participation, including brain MRI and inflammation markers.
Interventions
DRUG[18F]NOS
\[18F\]NOS is an investigational radiotracer which each subject will have one \[18F\]NOS positron emission tomography/computed tomography (PET/CT) scan performed.
Sponsors
University of Pennsylvania
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
(HC and PD cohorts) 1. Participants will be 18-75 years of age. 2. Participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures. 3. Subjects with known neuropsychiatric disorder may be eligible if, in the opinion of an investigator, the psychiatric condition would not compromise subject safety or successful participation in the study. Inclusion Criteria (PD cohort only) 1. History of diagnosis of probable idiopathic PD derived from UK Brain Bank Diagnostic criteria(1) per neurologist review. 2. Diagnosed with Parkinson's Disease at least 3 year prior to enrollment. 3. Subjects will be selected who have the capacity to give their own informed consent, in the opinion of a neurology investigator.
Exclusion criteria
(HC and PD cohorts) 1. Females who are pregnant or breast feeding at the time of screening will not be eligible for this study; a urine pregnancy test will be performed in women of child- bearing potential within one day of the PET/CT scan. 2. At screening, the participant's weight is \> 350 lb. 3. Subject reported claustrophobia that in the opinion of an investigator would interfere with acquisition of the structural MRI required for PET co-registration, and/or the PET scan itself. 4. History of epilepsy or seizure disorder as assessed by medical record review and/or self-report. 5. History of head trauma that in the opinion of an investigator may interfere with the uptake of applicable radiotracer as assessed by medical record review and/or self- report. 6. Current tobacco or nicotine dependence. History of greater than 5 pack years of smoking and less than 2 years since smoking cessation. 7. Self-reported current alcohol consumption of greater than or equal to 25 drinks per week. 8. Inability to tolerate imaging procedures in the opinion of an investigator or treating physician. 9. Any current medical condition, illness, or disorder as assessed by medical record review and/or self-reported that is considered by a physician or investigator to be a condition that could compromise participant safety or successful participation in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Characterize the uptake of [18F]NOS | 3 years | Characterize the uptake of \[18F\]NOS in the human brain for healthy controls and PD patients. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Compare patterns of uptake | 3 years | Compare patterns of \[18F\]NOS brain uptake in patients with PD versus healthy controls. |
| Compare peripheral blood inflammatory biomarkers | 3 years | Compare peripheral blood inflammatory biomarkers, including cytokines and mtDAMPs, in PD patients with healthy controls. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORJacob Dubroff, MD
University of Pennsylvania
Outcome results
None listed