Wound Sepsis
Conditions
Brief summary
efficacy of adding azithromycin to cephalosporin before cesarean delivery
Detailed description
efficacy of adding azithromycin to cephalosporin for the prophylaxis against infectious morbidity following cesarean delivery in high risk women
Interventions
DRUGcephalosporin
72 women will receive single antibiotic chemotherapy(Cefazolin) 2 gm iv within 30 minutes before skin incision
72 women will receive combined antibiotic chemotherapy azithromycin(Azrolid) 1 gm single oral dose 2 hours before cesarean delivery +cephalosporin(Cefazolin) 2 gm iv within 30 minutes before skin incision
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
17 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
* age between 17 and 39 years * gestaional age between 37 to 42 weeks * elective cesarean delivery * obese women
Exclusion criteria
* diabetic women on corticosteroids * intraopertaive complication in previous section * history of septic woun * prelabour rupture of membrane \>12 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| % of women with wound infection | after 14 days post cesarean delivery | superficial and deep surgical site wound infection will be looked for by laboratory confirmation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| % of women with postpartum endometritis | after 14 days post cesarean delivery | fever, abdominal pain , uterine tenderness will be looked for |
Countries
Egypt
Outcome results
None listed