Anorexia Nervosa, Bulimia Nervosa, Eating Disorders
Conditions
Keywords
rTMS
Brief summary
This is a pilot study to test the efficacy of repetitive transcranial magnetic stimulation (rTMS) in treating individuals with Anorexia Nervosa and Bulimia Nervosa. The main objective of this study is to determine the short and long-term efficacy of repetitive transcranial magnetic stimulation (rTMS) in reducing eating disorder symptoms (i.e. binging, purging, restricting, intense fear of gaining wait, etc;) in Anorexia Nervosa and Bulimia Nervosa. The investigators will also be comparing the brain activity patterns of individuals with Anorexia Nervosa and Bulimia Nervosa to healthy controls using electroencephalography (EEG). Further, the investigators would like to examine if the activation patterns in these patients change after receiving rTMS.
Interventions
DEVICERepetitive Transcranial Magnetic Stimulation
A non-invasive method of brain stimulation.
DEVICESham Transcranial Magnetic Stimulation
A device designed to look, sound, and feel like a real magnetic stimulation coil without actually stimulating the brain.
Sponsors
University of Manitoba
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Confirmed diagnosis of Anorexia Nervosa or Bulimia Nervosa, must pass rTMS screening questionnaire
Exclusion criteria
* Diagnosis of another psychiatric disorder, except MDD. * Any rTMS counter-indications: * History of seizures * Metal in head * Currently pregnant * Having received rTMS for any reason in the past as this would interfere with participant blinding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weekly Binge/Purge Frequency on Eating Disorder Examination | baseline, after week 1, week 2, and week 3 of treatment, 3 months post treatment, and 6 months post treatment. | Outcome measured by change of binge/purge episodes from baseline to the end of treatment. If the participant has a final score of 0 binges and 0 purges they will be considered in remission. A 50% improvement will be defined as a response to the rTMS. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Beck Anxiety Inventory (BAI) | baseline, after week 1, week 2, and week 3 of treatment, 3 months post treatment, and 6 months post treatment. | Outcome range: 0-63, with higher scores reflecting higher levels of anxiety. A total of 21 questions are summed for a total score out of 63. |
| Change in Beck Depression Inventory (BDI) | baseline, after week 1, week 2, and week 3 of treatment, 3 months post treatment, and 6 months post treatment. | Outcome range: 0-63, with higher scores reflecting higher levels of depression. A total of 21 questions are summed for a total score out of 63. |
Outcome results
None listed