Effects of Filter Ventilation on Sensory Response, Smoking Topography, and Inhalation in Current Every Day Cigarette Smokers

Effects of Filter Ventilation on Sensory Response, Smoking Topography, and Inhalation (COMET 2 2.1)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04060446

Enrollment

Registered

2019-08-19

Start date

2019-06-06

Completion date

2020-03-02

Last updated

2022-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cigarette Smoker, Current Every Day Smoker

Brief summary

This trial examines the effects of filter ventilation on sensory response, smoking topography, and inhalation in current every day cigarette smokers. The physical design features of cigarettes directly impact their appeal by influencing cognitive and sensory perceptions. The introduction of a now common design feature, filter ventilation, has led to greater public harm than benefit because of the potential for greater toxicity while enhancing product appeal among smokers. Ventilated cigarettes dilute smoke, which promotes perceptions of ?smoothness? and therefore lower health risk, contributing to the overall appeal of these products. The purpose of this study is to assess whether removing ventilation from cigarette filters lowers cigarette product appeal among smokers.

Detailed description

PRIMARY OBJECTIVES: I. To assess the link between marketing proxies for filter ventilation (product descriptors, packaging) and risk beliefs. OUTLINE: Patients smoke 5 cigarettes separated by 30 minute washout periods. Between 48 hours and 1 week later, patients smoke another 5 cigarettes separated by 30 minute washout period with CReSSMicro topography measurement device and BioRadio device for recording inhalation patterns.

Interventions

DEVICEMedical Device

Smoke cigarettes with CReSSMicro topography measurement device and BioRadio device

OTHERQuestionnaire Administration

Ancillary studies

BEHAVIORALTobacco Smoking

Smoke cigarettes

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 69 Years

Healthy volunteers

Yes

Inclusion criteria

* Currently smoking daily at least 5 cigarettes per day for at least one year * Primarily using factory-made filtered cigarettes with filter ventilation * Fair and above physical health * Fair and above mental health * Not actively trying to quit smoking or planning to quit in the next 30 days * Able to converse, read, and write in English * No alcohol or illegal drug use * Not pregnant or breastfeeding

Exclusion criteria

* Currently smoking daily less than 5 cigarettes per day for at least one year * Using roll-your-own cigarettes or unventilated filter cigarettes * Currently using any other tobacco product daily * Actively trying to quit smoking or planning to quit in the next 30 days * Not able to converse, read, and write in English * Adults unable to consent * Prisoners * Poor physical health by self report * Poor mental health by self report * Alcohol and illegal drug use * Pregnant or breastfeeding by self report

Design outcomes

Primary

Measure	Time frame	Description
Modified Cigarette Evaluation Questionnaire	Up to 210 minutes	Scored using an established algorithm. This results in 3 subscales (psychological reward, relief, reward) and 2 single items (aversion, respiratory sensation).

Secondary

Measure	Time frame	Description
Carbon monoxide (CO) boost	Up to 210 minutes	Defined as the difference between pre-smoking exhaled CO and postsmoking exhaled CO.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026