Pneumoperitoneum and Trendelenburg Position on Fluid Responsiveness

Influence of Pneumoperitoneum and Trendelenburg Position on Fluid Responsiveness Predicted by Pulse Pressure Variation and Stroke Volume Variation During Anaesthesia for Laparoscopic Gynaecological Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04060069

Enrollment

Registered

2019-08-16

Start date

2016-10-01

Completion date

2017-07-01

Last updated

2019-08-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fluid Responsiveness

Brief summary

The increased intraabdominal pressure and intrathoracic pressure due to pneumoperitoneum negatively affect the cardiovascular system, relatively dynamic parameters may vary due to intraoperative fluid therapy.

Detailed description

After the general anaesthesia induction and intubation, dynamic parameters such as SVV and PPV were monitored by pulse contour analysis.

Interventions

OTHERRinger Lactate

Fluids

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age\>18 years old patients * Will undergo elective laparoscopic gynecological surgery * ASA I-II

Exclusion criteria

* Obese patients (body mass index\> 30 kg.m2) * Patients who had arrhythmia * Patients who had cardiac insufficiency.

Design outcomes

Primary

Measure	Time frame	Description
to evaluate how stroke volume variation (%) affected during the Trendelenburg position and pneumoperitoneum	up to 10 months	to evaluate reliability of stroke volume variation in evaluating the response to fluid administration
to evaluate how pulse pressure variation (%) affected during the Trendelenburg position and pneumoperitoneum	up to 10 months	to evaluate reliability of pulse pressure variation in evaluating the response to fluid administration

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026