Bipolar Depression, Unipolar Depression
Conditions
Keywords
Electroconvulsive Therapy, Magnetic Resonance Imaging
Brief summary
This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.
Detailed description
This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar and bipolar depression receiving ECT. Patients will be scanned before and after a full course of ECT and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of ECT at the circuit level (2) to determine the mechanism of action of iatrogenic amnesia caused by ECT at the circuit level (3) to study the use of fcMRI as a state biomarker for depression (4) to study the use of fcMRI as a predictor of response for depression.
Interventions
DEVICEElectroconvulsive Therapy
Electrical currents are passed through the brain to intentionally trigger a controlled seizure in order to produce a therapeutic change in neuro-chemistry and circuitry.
Sponsors
Massachusetts General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and Females Between Ages of 18 and 65 * Diagnosis of Major Depressive Disorder without Psychotic Features or Bipolar I/II * Requiring ECT Treatment as Part of Psychiatric Care
Exclusion criteria
* Comorbid diagnoses of Major Depressive Disorder with Psychotic Features, Schizoaffective Disorder, Schizophrenia or Dementia * History of Psychosis * Substance Use Disorder (Abuse or Dependence) with Active Use Within Last 6 Months * Severe or Unstable Medical Illness * Medical Contraindication to Anesthesia or ECT (e.g., Recent Myocardial Infarction)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Functional Connectivity of Key Nodes | Through Treatment Completion, Average of 2 Months | Measured by Magnetic Resonance Imaging, Key Nodes include Subgenual Cingulate, Dorsal Anterior Cingulate, Nucleus Accumbens, Hippocampus, Amygdala and Dorsolateral Prefrontal Cortex |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Functional Connectivity of Memory Circuits | Through Treatment Completion, Average of 2 Months | Measured by Magnetic Resonance Imaging, Memory Circuits Include Hippocampus and Dorsolateral Prefrontal Memory Hubs |
Countries
United States
Outcome results
None listed