Cognitive Change, Musculoskeletal Pain
Conditions
Keywords
cognitive decline, pain, osteopathic manipulative treatment
Brief summary
Patients with pain commonly experience cognitive impairment. While symptoms of pain are effectively treated with osteopathic manipulative treatment (OMT), the cognitive piece is vastly ignored. Pain-induced cognitive dysfunction can be severe and is particularly apparent in working memory and attention. There is good reason to also expect cognitive responsiveness to OMT. Previous research has already reported related psychiatric outcomes, including relief from stress, self-perception and anxiety, suggesting that OMT may produce more global effects on cortical processing than currently thought.
Detailed description
Patients with pain commonly experience cognitive impairment. While symptoms of pain are effectively treated with osteopathic manipulative treatment (OMT), the cognitive piece is vastly ignored. Previous research has already reported related psychiatric outcomes, including relief from stress, self-perception and anxiety, suggesting that OMT may produce more global effects on cortical processing than currently thought. The current study is designed to extend previous research in several ways: 1. To describe the neuropsychological (NP) characteristics of adults with pain within an osteopathic and allopathic setting 2. To correlate NP with clinical outcomes (pain severity, number/location of osteopathic lesions) 3. To determine if OMT is associated with improved NP function. 4. To use saliva to measure cytokine concentration of IL-1β,IL-6, IL-8, TNF-α 5. To correlate cytokine concentrations with clinical outcomes (pain severity, number/location of osteopathic lesions, NP)
Interventions
OTHEROsteopathic Manipulative Treatment
Osteopathic manipulative treatment (OMT) is defined as the therapeutic application of manually guided forces by an osteopathic physician to improve physiologic function and/or support homeostasis that has been altered by somatic dysfunction. Somatic (body framework) dysfunction or altered function of related components is observed in the skeletal, arthrodial and myofascial structures, and their related vascular, lymphatic, and neural elements. Techniques can use a direct method where the restrictive barrier is engaged and a final activating force is applied to correct the somatic dysfunction, or an indirect method where the restrictive barrier is disengaged and the dysfunctional body part is moved away from the restrictive barrier until tissue tension is equal in one or all planes and directions
OTHERControl- No Intervention
This group will refrain from getting OMT while in the study.
Sponsors
Midwestern University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. 40 years of age or older; 2. seeking treatment for acute or chronic pain (neck, thoracic, shoulder, back) 3. gives a positive response to the item, Have you had thinking problems because of your pain?; 4. agree to forego extra-trial manipulation (e.g., massage, chiropractic, physical therapy); 5. Score \> 23 on the Telephone Interview for Cognitive Status; 6. written informed consent.
Exclusion criteria
1. recent (\< 2 month) or planned surgery within the duration of the study; 2. use of medication that could interfere with cytokine measurements; 3. recent (\< 2 month) changes to psychotropic medication within the duration of the study; 4. history of manipulation within the past six months. 5. diagnosed neurocognitive disorders; 6. contraindication to receiving OMT.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| inflammatory marker | baseline, week 8, week 12 | TNF Alpha |
| neuropsychology change | baseline, week 8, week 12 | standardized assessment battery |
| pain scale change | baseline, week 8, week 12 | 1-10 |
| inflammatory markers change | baseline, week 8, week 12 | cortisol |
| Inflammatory marker | baseline, week 8, week 12 | IL 6 |
Countries
United States
Outcome results
None listed