Outcome of Patients With Thoraco-abdominal Injury and Stress-induced Hyperglycemia or Diabetic Hyperglycemia

Admission Hyperglycemia in Patients With Moderate to Severe Thoracoabdominal Injuries is Associated With Higher Mortality Rate Than Non-Diabetic Normoglycemic Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04058015

Enrollment

802

Registered

2019-08-15

Start date

2019-06-03

Completion date

2019-08-09

Last updated

2019-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal Injury, Hyperglycemia, Hyperglycemia Stress, Thoracic Injury

Keywords

admission hyperglycemia, stress-induced hyperglycemia, diabetic hyperglycemia, diabetes mellitus, thoracoabdominal trauma, mortality

Brief summary

This study aimed to measure the effects of SIH and DH on the mortality outcomes of the adult patients with moderate to severe thoracoabdominal injury

Detailed description

Because the pathophysiologic response of the patients with a thoracoabdominal injury is different from those who had a traumatic brain injury, this study aimed to measure the effects of hyperglycemia induced by stress or by diabetes on the outcomes of patients with thoracoabdominal injuries in comparison with those who had non-diabetic normoglycemia (NDN). The primary study hypothesis stated that, following thoracoabdominal injuries, the patients with SIH had a worse outcome than patients with DH. The primary outcome was mortality rate of these patients.

Interventions

OTHERStress-induced hyperglycemia

Stress-induced hyperglycemia (SIH)was defined as a serum glucose ≥ 200 mg/dL in the patients without Diabetes mellitus.

OTHERDiabetic hyperglycemia

Diabetic hyperglycemia (DH) which indicated a serum glucose ≥ 200 mg/dL in patients with Diabetes mellitus.

OTHERDiabetic normoglycemia

Diabetic normoglycemia (DN), which was defined when there was a serum glucose \< 200 mg/dL in the patients with Diabetes mellitus.

OTHERNon-diabetic normoglycemia

Non-diabetic normoglycemia (NDN) indicating a serum glucose \< 200 mg/dL in patients who were absent of Diabetes mellitus.

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 100 Years

Healthy volunteers

Inclusion criteria

* adult patients with moderate to severe thoracoabdominal injuries

Exclusion criteria

* patients with a thoracic and abdominal abbreviated injury scale (AIS) \< 3 * patients who had polytrauma which was defined as there was additional AIS scores ≥ 3 points in other regions of the body * patients less than 20 years old * patients who had sustained a burn injury

Design outcomes

Primary

Measure	Time frame	Description
in-hospital mortality	up to 6 months	The primary outcome of the study was in-hospital mortality.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026