Transthoracic Ultrasound in the Diagnosis and Follow-up of Ventilator Associated Pneumonia

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04057625

Enrollment

Registered

2019-08-15

Start date

2019-09-30

Completion date

2020-10-31

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Ultrasound, Ventilator Associated Pneumonia

Brief summary

To evaluate the sensitivity, specificity and diagnostic accuracy of bedside transthoracic ultrasound examination in the diagnosis and follow up of ventilator associated pneumonia.

Detailed description

VAP is the most frequent hospital-acquired infection in intensive care units. Depending on the diagnostic criteria used, its incidence ranges from 5% to 67%. The risk of acquiring VAP is 3% per day during the first 5 days on mechanical ventilation, and it is decreased to 1% per day for the following days. VAP is suspected when subject shows high grade fever, increase in leukocyte count, change in color of sputum and tachypnea. It's a leading cause of mortality in 15- 65% of the cases. Serial chest x-ray for diagnosis and follow up, done at time of diagnosis, after 5 days and after 10 days. Chest radiography is consistently carried out after LUS , LUS is done every other day, measuring the largest area of consolidation according to the intercostal space and direction of the probe . Chest radiography is read by two physicians.

Interventions

DEVICEtransthoracic ultrasound

using transthoracic ultrasound in the diagnosis and follow up of vap,measuring the largest area of consolidation according to intercostal space and the direction of the probe.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Mechanical ventilation for at least 48 hours. * New or evolving infiltrate on chest radiograph (CXR). * Clinical pulmonary infection score more than or equal 6

Exclusion criteria

* Patients who are less than 18 years old. * Patients who have evidence of pneumonia before or prior to being mechanically ventilated. * Patients with pulmonary infarction.

Design outcomes

Primary

Measure	Time frame	Description
detecting ultrasound efficiency in diagnosis and follow up of vap	baseline	Sensitivity, specificity, and diagnostic accuracy of lung ultrasound to diagnose and follow up ventilator-associated pneumonia.

Secondary

Measure	Time frame	Description
icu stay	baseline	Duration of stay in ICU.
hospital stay	basline	Duration of hospital stay.
mortality	basline	mortality from vap

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026