Autonomic Nervous System, Heart Rate Variability, Muscle Sympathetic Nerve Activity
Conditions
Keywords
Heart rate variability, MSNA, vagus nerve, sympathetic nervous system
Brief summary
To demonstrate the effect of non invasive vagus nerve (VNS) stimulation on heart rate variability and MSNA signal.
Detailed description
First part: Assessment of the muscle sympathetic nerve activity (MSNA) at baseline using microneurography performed on the superficial peroneal nerve. Second part: Acquisition of the MSNA signal during non-invasive VNS and apnea. Non-invasive VNS is performed using several frequencies of stimulation. Maximal and voluntaries apnea are performed at the end of the expiration. Continuous recording of the following parameters: * non-invasive arterial blood pressure * R-R interval * electrocardiogram * MSNA activity * respiratory curve signal * respiratory rate, oxygen saturation
Interventions
OTHERModulation of muscle sympathetic nerve activity
Assessment of muscle sympathetic nerve signal and exposition to external non invasive modulation.
Sponsors
Erasme University Hospital
Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Masking description
Investigators are double-blinded for both experimental procedures and data analyzes. Volunteers are blinded to the site of stimulation.
Intervention model description
Randomized, controlled, double-blind, cross-over study
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * \>18 years old
Exclusion criteria
* pregnancy and breastfeeding * smoke * alcool/energy drinks/coffee consumption, exertion 24h before the participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate variability modulation | 4 hours | Modulation of heart rate variability assessed through analysis of MSNA signal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Non-invasive vagus nerve stimulation | 4hours | Modulation of parasympathetic tone based on two different frequencies stimulation |
| Profile of response for MSNA | 4 hours | To describe positive and negative patterns of MSNA response |
Other
| Measure | Time frame | Description |
|---|---|---|
| Profile of response of MSNA during prolonged breath hold | 4hours | Modulation of MSNA activity during repetitive prolonged breath hold |
Countries
Belgium
Contacts
Primary ContactAnaïs Gauthey, MD
Outcome results
None listed