Umbilical Cord; Clamping Time
Conditions
Brief summary
Stem cell therapies have been promising therapies in neonatal morbidities such as bronchopulmonary dysplasia, intraventricular hemorrhage and hypoxic ischemic encephalopathy. Although researchers showed those effects by several mechanisms including paracrine effect, regenerative and restorative effects, there is no obvious recommendations for the type of stem cells, dosage or the route of administration the cells. The usage of exogenous stem cells can be difficult due to technical issues in preterm infants. In the presence of these data, the amount of endogenous stem cells passing through the cord to the infant may show differences in terms of delayed cord clamping and milking. Therefore the aim of this prospective randomized study is to determine the quantity of the stem cells according to delayed cord clamping or cord milking. We also aimed to evaluate the association between the number of stem cells and neonatal morbidities.
Interventions
PROCEDUREDelayed umbilical cord clamping
During the C section, infants' umbilical cord clamping will be delayed for 30-60 seconds.
PROCEDURECord Milking
Umbilical cord will be milked from th distance of 20cm from mother's side to the baby, for 3-4 times.
Sponsors
Turkish Neonatology Society
Kanuni Sultan Suleyman Training and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
No minimum to 30 Minutes
Healthy volunteers
Yes
Inclusion criteria
* Infants born under 32 weeks of gestation * Accepted to participate with informed consent * History of healthy pregnancy * Infants born and will be followed up at the study hospital
Exclusion criteria
* Congenital abnormalities * Chromosomal abnormalities * Declined to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of Stem cells | 6 months | Determining the quantity of endogenous stem cells transmitted through the umbilical cord to the infant after different types of cord clamping. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with Neonatal Morbidities | 6 months | Recording newborn morbidities such as intraventricular hemorrhage , necrotizing enterocolitis, bronchopulmonary dysplasia , retinopathy of prematurity which are detected in the study population. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactSeda Yilmaz Semerci
Outcome results
None listed