Neuronal Intranuclear Inclusion Disease
Conditions
Brief summary
To discover the microstructure, macrostructure and functional changes with 7T multi-modal magnetic resonance imaging of Neuronal Intranuclear Inclusion Disease, and to explore new biomarkers for evaluating the severity and the progression of Neuronal Intranuclear Inclusion Disease.
Interventions
None listed
Sponsors
Zhejiang University Interdisciplinary Institute of Neuroscience and Technology
First Affiliated Hospital of Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
1. Patients diagnosed with NIID 2. Older than 18 years; 3. Sign the informed consent form.
Exclusion criteria
1. The informed consent is withdrawn by the subject; 2. Contraindications or intolerance to MRI: metallic foreign bodies, instability of vital signs, epilepsy, claustrophobia, etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fractional anisotropy (FA) | baseline | Parameters to describe integrity of white matter in diffusion MR Imaging |
| mean diffusivity (MD) | baseline | Parameters to describe integrity of white matter in diffusion MR Imaging |
| Intracellular volume fraction(icvf) | baseline | Parameters to describe integrity of white matter in diffusion MR Imaging |
| orientation dispersion index (ODI) | baseline | Parameters to describe integrity of white matter in diffusion MR Imaging |
| fiber number(fiber pass through the lesions) | baseline | Parameters to describe integrity of white matter in diffusion MR Imaging |
| short-range and long-range functional connectivity around the lesions at rest | baseline | Functional network connectivity impairments in patients |
Countries
China
Contacts
Primary ContactHui Liang, Doctor
Backup ContactDaqiang Ke, Bachelor
Outcome results
None listed