PONV
Conditions
Keywords
Penehyclidine, PONV
Brief summary
Patients scheduled for elective strabismus surgery under general anesthesia in the First Affiliated Hospital of Nanjing Medical University will be included in this study. Patients 1)ASA I or II, 2)aged 3-65 years, 3)scheduled for elective strabismus surgery under general anesthesia, will be included in the study. Patients 1)had prior PONV, 2)severe motion sickness, 3)a history of ophthalmic surgery, 4)had received drugs known to have antiemetic effects, will be excluded from the study. The primary aim is to evaluate the prophylaxis effect of penehyclidine(a novel long acting selective anticholinergic agent developed in China) on postoperative nausea and vomiting after strabismus surgery. Secondary outcomes include the effect of PONV risk factors and surgical technique on PONV rank score, occurance of oculocardiac reflex, time to extubation.
Interventions
DRUGPenehyclidine
Patients receive penehyclidine 10μg/kg(up to 0.5mg, diluted with normal saline to 0.1mg/ml) after anesthesia intubation.
DRUGnormal saline
Patients receive 0.1ml/kg normal saline(up to 5ml) after anesthesia intubation.
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
3 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* ASA I or II * Aged 3-65 years * Scheduled for elective strabismus surgery under general anesthesia
Exclusion criteria
* Had prior PONV * Severe motion sickness * A history of ophthalmic surgery * Had received drugs known to have antiemetic effects in 24h before surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of PONV | From extubation to 48 hours after surgery | Occurance of postoperative nausea and vomiting after strabismus surgery |
Countries
China
Outcome results
None listed