Aging, Frailty, Sarcopenia
Conditions
Brief summary
The aim of the current study, therefore, is to determine the feasibility of recruitment and adherence to resistance exercise training interventions performed at low and high loads, to volitional muscular failure, in a trial population that includes both healthy and frail older people.
Interventions
BEHAVIORALLow Load Resistance exercise
leg extension, leg press, leg curl and calf press
BEHAVIORALHigh Load Resistance exercise
leg extension, leg press, leg curl and calf press
Sponsors
University of Glasgow
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Over age of 65 years
Exclusion criteria
* Current participation in an exercise programme * Exercise deemed unsafe by clinical team
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle strength | Change from baseline to 8 weeks | Knee extensor maximal torque during an isometric MVC |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle strength | Change from baseline to 8 weeks | Knee flexor maximal torque during an isometric MVC |
| One-repetition maximum | Change from baseline to 8 weeks | leg extension, leg curl, leg press and calf press |
| Vastus lateralis muscle thickness | Change from baseline to 8 weeks | Measured via ultrasound |
| Short performance physical battery test | Change from baseline to 8 weeks | SPPB - balance, walking pace and chair rise |
| Quality of life measure | Change from baseline to 8 weeks | EQ-5D-5L questionnaire |
| Biomechanics during walking and stair climbing | Change from baseline to 8 weeks | Motion analysis |
Countries
United Kingdom
Outcome results
None listed