Periodontitis
Conditions
Keywords
Gingival Crevicular Fluid, Lipid Mediator, Periodontal Treatment
Brief summary
The aim of this study was to evaluate the levels of lipoxin A4 (LXA4), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in gingival crevicular fluid (GCF) and saliva in individuals with periodontal healthy and chronic periodontitis. In addition, the investigators evaluated the levels of these mediators after non-surgical periodontal treatment in patients with chronic periodontitis. A total of 20 subjects, 10 patients with chronic periodontitis (CP) and 10 periodontally healthy individuals were included in the study. Clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment levels (CAL) were recorded. GCF and saliva samples were obtained at the beginning of the study from all individuals. GCF and saliva samples were re-collected from patients with CP at 1 month after non surgical periodontal therapy.
Interventions
PROCEDURENon-surgical periodontal treatment
Mechanical non-surgical treatment were performed
Sponsors
Ordu University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Have at least 20 natural teeth, excluding third molars. * Chronic periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and clinical attachment level (CAL) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting \>30% of the teeth, as detected on clinical and radiographical examinations. * Periodontally healthy control group had no sign of gingival inflammation, no PD \> 3mm and no evidence of attachment or bone loss.
Exclusion criteria
* History of systemic disease. * Regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study. * Periodontal treatment during last 6 months that could affect periodontal status. * Smoking. * History of radiotherapy or chemotherapy. * Ongoing orthodontic treatment. * Aggressive periodontitis. * Current pregnancy, lactation or menopause.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lipoxin A4 levels | 1st month | change of gingival crevicular fluid and salivary Lipoxin A4 levels from baseline at 1st month |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prostaglandin E2 levels | 1st month | change of gingival crevicular fluid and salivary Prostaglandin E2 levels from baseline at 1st month |
| Leukotriene B4 | 1st month | change of gingival crevicular fluid and salivary Leukotriene B4 levels from baseline at 1st month |
Countries
Turkey (Türkiye)
Outcome results
None listed