Neonatal Respiratory Distress
Conditions
Brief summary
The investigators hypothesize that there is a growing trend of the feasibility of HFNC as an alternative to other forms of non-invasive ventilation mechanism to provide continuous distending pressure to preterm infants. However, there remains uncertainty about the efficacy and safety of HFNC in this population.
Detailed description
Our primary outcome is to determine whether postextubation respiratory support via heated humidified high-flow nasal cannula results in a greater proportion of infants younger than 34 weeks gestation being successfully extubated after a period of endotracheal positive pressure ventilation compared with conventional (NCPAP). The following study will be conducted in the neonatal intensive care unit (NICU) of Gynecology and Obstetric department of Kasr El Aini hospital and neonatal intensive care unit of Military Hospital throughout a time interval of at least 6 months for a minimum of 100 preterm infants. Infants will be eligible for the study if they born at less than 34 weeks' gestation, required endotracheal intubation and positive pressure ventilation, and considered ready for extubation by the clinical team. The investigators will assign extubation of preterm ventilated infants (50 preterm infant) in NICU of Military Hospital into HHFNC and extubation of preterm ventilated infants (50 preterm infant) in (NICU) of Gynecology and Obstetric department of Kasr El Aini hospital into NCPAP (50 preterm infant).
Interventions
DEVICEHigh flow nasal cannula vs. Nasal continuous positive airway pressure
High flow nasal cannula
Sponsors
Ramy Saleh Morsy
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 28 Days
Healthy volunteers
Yes
Inclusion criteria
•Infants born at a gestational age of less than 34 weeks, receiving mechanical ventilation through an endotracheal tube.
Exclusion criteria
* Full term neonates or large for gestational age. * Preterm neonates not supported primarily by invasive ventilation. * Infants with suspected upper airway obstruction, congenital airway malformations or major cardiopulmonary malformations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postextubation respiratory support | through study completion, an average of 1 year | compare successful extubation of preterm (less than 34 weeks) into high flow nasal cannula versus continues positive airway pressure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postextubation respiratory support follow up | through study completion, an average of 1 year | Secondary outcomes include the following: 1. Need for delayed reintubation (beyond 7 days) 2. Incidence of bronchopulmonary dysplasia. 3. Total number of days of hospital stay. |
Countries
Egypt
Outcome results
None listed