Acute Myocardial Infarction
Conditions
Keywords
Acute Myocardial Infarction, Registry, Outcomes, Medico-economic evaluation, Comorbidities
Brief summary
Over the last two decades, considerable progress has been made in the management of Acute Myocardial Infarction (AMI), both in the acute phase and in monitoring beyond the hospital phase. Nevertheless, the evolution of care practices and their impact on the mid- and long-term prognosis of patients admitted to the intensive care unit for acute myocardial infarction remain relatively little studied exhaustively. The aim of this study is to assess the profile of AMI patients, their management and follow-up in order to evaluate the relationship between these factors and outcomes.
Detailed description
The FRENCHIE registry is a French multicenter prospective observational study. All the eligible consecutive patients admitted within 48 hours after symptom onset in a cardiac ICU for an acute myocardial infarction. This hospital registry will be linked to the national databases, in order to collect follow-up clinical outcomes and health care consumption.
Interventions
None listed
Sponsors
Novartis
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Myocardial infarction (MI) within 48h of symptom onset, characterized by the typical increased or fall of troponin (or CPKMB) associated with at least one of the following elements : * Symptoms compatible with myocardial ischemia * Appearance of pathological Q waves * ST- T changes compatible with myocardial ischemia (ST segment elevation or depression, T-wave inversion) * Written consent. * Covered by French medical insurance (Sécurité Sociale)
Exclusion criteria
* Iatrogenic MI defined as MI occurring within 48h of a therapeutic procedure * AMI diagnosis invalidated in favor of another diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lipopretein 1 evolution | 9 months after the end of initial hospitalization | To evaluate plasma concentrations of Lpa and its dynamic pattern during hospital index and 3-9 months following hospitalization. |
| In-hospital mortality | Through the end of initial hospitalization, an average of 5 days | In-hospital mortality |
| In-hospital outcomes | Through the end of initial hospitalization, an average of 5 days | To measure the in-hospital major cardiovascular events : recurrence of AMI, myocardial revascularization, stroke |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Relationship between patients profile and mortality and non-cardiovascular morbidity outcomes according to management | Up to 20 years | All cause death and Non-cardiovascular events leading to to hospitalizations according to patient's management |
| Oral comorbidities | Up to 20 years | Prevalence of oral pathology and its relationship with early, mid, and long-term prognosis and outcomes |
| Sleep disordered breathing comorbidities | Up to 20 years | To assess the prevalence of sleep disordered breathing comorbidities and the relationship with early, mid, and long-term prognosis and outcomes |
| Cardiovascular outcomes during follow-up | Up to 20 years | All cause death and Cardiovascular events including non fatal Myocardial Infarction, non fatal stroke, revascularization, hospitalization for other cardiovascular causes including Bleeding leading to hospitalization |
| Evaluate the relevance of European Society of Cardiology (ESC), American Heart Association/American College of Cardiology (AHA / ACC) guidelines regarding management of AMI patients | Up to 20 years | Evaluate the relevance of ESC, AHA/ACC guidelines regarding management of AMI patients |
| Cost-utility: incremental (or decremental) cost-utility ratio during follow-up | Up to 20 years | Medical care costs for the index hospitalization and during follow-up period are assessed using a combination of resource-based and event-based methods. In-hospital resource utilization are based on diagnosis and procedural codes and length of stay. |
| Evaluate the path of care combined with patient care practices following an acute myocardial infarction | Up to 20 years | Evaluate the path of care and patient care practices following an acute myocardial infarction : Reimbursed or prescribed treatments, combined with number of visits, biological and tests performed |
| Non cardiovascular outcomes during follow-up | Up to 20 years | All cause death and Non-cardiovascular events leading to to hospitalizations |
| Relationship between patients profile and mortality and cardiovascular morbidity outcomes according to management | Up to 20 years | All cause death and cardiovascular events including non fatal MI, non fatal stroke, revascularization, hospitalization for other cardiovascular causes including Bleeding leading to hospitalization according to patient's management |
Countries
France
Contacts
Primary ContactTabassome SIMON
Backup ContactPhilippe Gabriel STEG
Outcome results
None listed