Cancer of Pancreas, Ossification, Heterotopic
Conditions
Keywords
Cancer of Pancreas, Ossification, Heterotopic, Abdominal incision
Brief summary
To investigate whether pancreatic cancer is the cause of heterotopic ossification of abdominal incision.
Detailed description
Heterotopic ossification of abdominal incision (HOAI) has long been regarded as a rare complication after general surgery. However,according to our retrospective analysis. HOAI was more frequently observed in the malignancy group (33/121 cases, 27.3%) than in the non- malignancy group. Because of the many biases in the retrospective analysis, the result was not widely shared. The purpose of this prospective study is to confirm that pancreatic cancer is the cause of heterotopic ossification of abdominal incisions. According to postoperative pathology, the patients were divided into two groups: pancreatic cancer group and benign diseases group.The researchers will observe whether patients develop heterotopic ossification of the abdominal incision one year after surgery to conclude.
Interventions
DIAGNOSTIC_TESTBone alkaline phosphatase
Hematologic indicators reflecting ossification.
RADIATIONAbdominal CT scan
Observe whether HOAI occurs.
Sponsors
Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Obtain informed consent from the patients. * The patient's abdominal incision was double-closed with continuous suture of linea alba and fascia with absorbable suture, and skin was sutured with skin staples.
Exclusion criteria
* Refusing to join the study * Previous history of malignant tumor * Previous history of midabdominal incision * Abnormal calcium and phosphorus metabolism * Distant metastasis * Palliative operation * performing neoadjuvant chemotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of HOAI | 12 months | HOAI is determined by CT, whose CT number is similar to that of the same spine. |
| Bone alkaline phosphatase | 12 months | Preoperative tests were performed and every three months postoperatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of distant metastasis and local recurrence | 12 months | Patients with pancreatic cancer were divided into HOAI and non-HOAI groups to determine whether there were differences in the incidence of distant metastasis and local recurrence between the two groups. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | 5 years | Patients with pancreatic cancer were divided into HOAI and non-HOAI groups to determine whether there were differences between the OS of two groups. |
Countries
China
Contacts
Primary ContactJishu Wei, MD,PhD
Outcome results
None listed