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Nasal High Flow in Bariatric Surgery

Effect of Nasal High Flow on Perioperative Oxygenation in Patients Undergoing Bariatric Surgery

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04048798
Enrollment
112
Registered
2019-08-07
Start date
2020-01-31
Completion date
2021-02-28
Last updated
2019-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morbid Obesity

Keywords

morbid obesity, bariatric surgery, high frequency nasal cannula, oxygenation

Brief summary

High frequency nasal cannula (HFNC) provides an inspiration O2 fraction of 21-1% and it has a minimal dead space and can be well tolerated due to humidified air. Group I patients will be applied HFNC before and after bariatric surgery, Group II patients will be applied a constant O2 concentration via face mask. Oxygen pressure, oxygen saturation, carbon dioxide, respiration frequency, forced vital capacity will be measured before and after surgery.

Detailed description

Morbid obese patients are prone to atelectasis and hypoxemia after bariatric surgery. High frequency nasal cannula (HFNC) provides an inspiration O2 fraction of 21-1% and it has a minimal dead space and can be well tolerated due to humidified air. It provides 5-7 cm H2O positive end expiratory pressure to the airways and may prevent atelectasis. In the preoperative room, forced vital capacity, peripheral oxygen saturation (SpO2), respiratory frequency, heart rate (HR), blood pressure (BP), carbon dioxide, oxygen pressure and carbon dioxide partial pressure values in blood gas analysis will be recorded. We will apply HFNC in the preoperative and postoperative period to Group I patients, while applying a constant O2 concentration to Group II patients. After appliying HFNC for two hours in Group I patients and O2 via face mask in Group II patients measurements will be repeated. During surgery, similar mechanical ventilation parameters will be applied to the patients. After the operation Group I patients will be applied HFNC, while Group II patients will be applied O2 via face mask in the recovery room for two hours. Measurements will be repeated. Primary end point of the study is the association between oxygen pressure, carbon dioxide partial pressure values among preoperative before and after HFNC and O2 and postoperative times.

Interventions

OTHEROxygen therapy via HFNC

Oxygen treatment will be applied to the patients via HFNC before and after surgery

OTHEROxygen therapy via face mask

Oxygen treatment will be applied to the patients via face mask before and after surgery

Sponsors

Istanbul University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* Patients with a body mass index of 40-55 kg/m2 * American Society of Anesthesiologists score II-III * Patients undergoing laparoscopic sleeve gastrectomy or one anastomosis gastric bypass

Exclusion criteria

* Obstructive sleep apnea syndrome * Using a non invasive mechanical ventilation device preoperatively * Patients whoo will predicted to postanesthesia care unit admission postoperatively

Design outcomes

Primary

MeasureTime frameDescription
PO2 value24 hoursPO2 value will be measured before HFNC or face mask, after HFNC or face mask and after surgery
PCO2 value24 hoursPO2 value will be measured before HFNC or face mask, after HFNC or face mask and after surgery

Contacts

Primary ContactCigdem A BEYOGLU
akyolbeyoglu@gmail.com+905052278176
Backup ContactGuniz Koksal
gunizkoksal@hotmail.com05424138505

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026