The Becoming of Children With Doose Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04048213

Acronym

DOOSE

Enrollment

Registered

2019-08-07

Start date

2019-06-01

Completion date

2023-06-27

Last updated

2026-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Doose Syndrome, Epileptic Syndromes, Learning Disabilities

Keywords

doose syndrome, Epileptic Syndromes, Learning Disabilities

Brief summary

Doose syndrome is a rare epileptic syndrome that can lead to learning difficulties and a poor quality of life. The goal of this study is to evaluate the evolution of epilepsy and its consequences on cognitive development and learning issues in children with Doose syndrome.

Detailed description

Doose syndrome is a rare epileptic syndrome beginning between ages two and five, characterized by myoclonic-astatic seizures which can be associated with myoclonic seizures, astatic seizures, absences and generalized tonic-clonic seizures. These seizures can be difficult to treat effectively and may lead to learning difficulties. During this study, parents of children with Doose syndrome will receive a questionnaire regarding learning disabilities, quality of life and epilepsy of their children.

Interventions

OTHERquestionnaire

questionnaire send to the parents

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 6 Years

Healthy volunteers

Inclusion criteria

* children with doose syndrome diagnosed between ages 1 and 6 * normal development until onset of seizures

Exclusion criteria

* unconfirmed diagnoses * abnormal diagnoses * abnormal psychomotor development before onset of seizures * cerebral MRI abnormalities * other child epileptic syndromes

Design outcomes

Primary

Measure	Time frame	Description
disease effects on the learning ability of children with doose syndrome	day of inclusion	disease effects on the learning ability of children with doose syndrome base on scholar informations

Secondary

Measure	Time frame	Description
Evolution of epilepsy in children with doose syndrome based on pathological symptoms	day of inclusion	Evolution of epilepsy in children with doose syndrome based on pathological symptoms

Countries

France

Contacts

PRINCIPAL_INVESTIGATORSylvie Nguyen, Pr

CHRU LILLE

PRINCIPAL_INVESTIGATORAxel Lebas, MD

CHU Rouen

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 13, 2026