Aging, Sarcopenia
Conditions
Brief summary
The aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. Half of the participants will receive krill oil supplements and the other half a placebo.
Interventions
DIETARY_SUPPLEMENTKrill Oil
Aker Biomarine Superba Krill Oil
DIETARY_SUPPLEMENTPlacebo
Mixed vegetable oil
Sponsors
University of Glasgow
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* BMI less than 35kg/m2
Exclusion criteria
* Diabetes * severe cardiovascular disease * seizure disorders * uncontrolled hypertension (\>150/90mmHg at baseline measurement) * cancer or cancer that has been in remission \<5 years * ambulatory impairments which would limit ability to perform assessments of muscle function * dementia * taking medication known to affect muscle (e.g. steroids) * have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump) * on anticoagulant therapy * allergies to seafood * regular consumption of more than 2 portions of oily fish per week.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Muscle strength | Change from baseline to 6 months | knee extensor muscle strength |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Grip strength | Change from baseline to 6 months | Grip strength |
| Change in Blood lipids | Change from baseline to 6 months | Blood lipids |
| Change in Muscle thickness | Change from baseline to 6 months | Vastus lateralis muscle thickness |
| Change in Short performance physical battery test | Change from baseline to 6 months | SPPB |
| Change in CRP | Change from baseline to 6 months | CRP |
| Change in Lean Mass | Change from baseline to 6 months | Measured by BIA |
| Change in Fasting glucose | Change from baseline to 6 months | Fasting glucose |
| Change in Erythrocyte fatty acid profile | Change from baseline to 6 months | Erythrocyte fatty acid profile |
| Change in Body Fat | Change from baseline to 6 months | Measured by BIA |
Countries
United Kingdom
Outcome results
None listed