Cone Beam CT Guided Transbronchial Cryobiopsy

Conditions

ILD

Brief summary

Interstitial lung diseases (ILD) are common in clinical practices and need multidisciplinary assessment of clinical presentations, radiological and histological features. Transbronchial cryobiopsy (TBCB) is one of the most important invasive procedures for ILD when a confident diagnosis cannot be made by clinical and radiological assessment. TBCB could lead to higher incidence of risks. The pneumothorax and severe bleeding seemed to be more common in patients with TBCB. Cone-beam computed tomography (CBCT) could provide 3-dimensinal (3D) CT images which were close to the image qualities of conventional CT. The probe-to-pleura relationship could be accurately established by the 3D CT scan and the cryobiopsy safety profile might be improved under the guidance of CBCT. In this study, we conducted a prospective study to observe the safety and diagnostic efficacy of CBCT guided TBCB for the DPLD patients.

Bian Y, Deng M, Gao Q, Zhou G, Tong R, Zhao L, Liu M, Sun J, Dai H, Herth FJF, Hou G, Wang C.

2024-06-234 citations

10.1007/s00408-024-00713-2

Assessment of a randomized controlled trial on the safety of pre-placing bronchial balloons in transbronchial lung cryobiopsy for diagnosing interstitial lung disease

Yiding Bian, Guowu Zhou, Qian Gao, Mingming Deng, Run Tong et al. (9 authors)

European journal of medical research2024-05-031 citations

10.1186/s40001-024-01871-y

The associations of radiological features of high-resolution computed tomography with the outcomes of transbronchial cryobiopsy in interstitial lung diseases: A cohort study

Guowu Zhou, Yanhong Ren, Jun Li, Ting Yang, Nan Su et al. (13 authors)

Frontiers in Medicine2022-08-022 citations

10.3389/fmed.2022.959129

The effect of 1.9-mm versus 2.4-mm probes in transbronchial cryobiopsies for interstitial lung diseases: a prospective analysis.

Zhou G, Ren Y, Li J, Yang T, Su N, Zhao L, Wang S, Wang D, Li Y, Tian Z, Liu R, Dai H, Wang C.

2021-01-019 citations

10.21037/atm-20-4159

Interventions

PROCEDUREcone beam CT guided transbronchial cryobiopsy

CBCT images are acquried and reviewed in axial, coronal and sagittal planes to most accurately assess the cryoprobe position within the lung parenchyma and relative to other thoracic structures. The minimum probe-to-pleura distance will be measured. If the position of cryoprobe is proper, TBCB will be perfomed.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* more than 18 years old, diffuse parenchymal lung diseases without a diagnosis after integration of clinical profile, laboratory tests and HRCT features, FVC more than 50%, DLCO more than 35%

Exclusion criteria

* acute exacerbation within one month, bleeding diathesis, anticoagulant therapy, using antiplatelet drugs, patients with pulmonary hypertension, respiratory failure, liver, kidney disfunction, and cardiac insufficiency, PLT less than 50 x 109/L

Design outcomes

Primary

Measure	Time frame	Description
safety profile of procedure	30 days	pneumothorax, bleeding severity, post-bronchoscopy fever, acute exacerbation of ILD, procedure related death.

Secondary

Measure	Time frame	Description
diagnostic efficacy	30 days	diagnostic yield

Countries

China

Outcome results

None listed