The Link Between Periodontitis, Smoking and Oral Cancer

Analysis of the Link Between Periodontitis, Smoking and Oral Cancer: Cohort Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04047212

Enrollment

200

Registered

2019-08-06

Start date

2021-08-12

Completion date

2032-01-30

Last updated

2021-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis, Oral Cancer

Brief summary

Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and esthetics causing social impairment. Consequently, periodontitis may end up causing marked impairment of the quality of life of the affected patients, impairment of general health and increasing the dental care costs significantly. Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to gingivitis. It then triggers the host cells to produce proteinases that mediate loss of marginal periodontal ligaments, apical migration of the junctional epithelium and apical spread of bacterial biofilm. Therefore, this research aims to identify the risk of smoking to both periodontitis and oral cancer, and the risk of periodontitis to oral cancer.

Interventions

DIAGNOSTIC_TESTbiopsy for oral cancer

surgical biopsy is to be taken for diagnosis of oral cancer or premalignant lesions

DIAGNOSTIC_TESTperiodontal examination

Periodontal clinical examination to all by periodontal charting

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients 18 years or older.

Exclusion criteria

* Patients with any systemic diseases. * Pregnant females. * Handicapped and mentally retarded patients. * Patients undergoing radiotherapy. * Patients having oral cancer

Design outcomes

Primary

Measure	Time frame	Description
Periodontitis	the 10 years of the study	arising of periodontitis or increase in the grade of an already existing case of periodontitis

Secondary

Measure	Time frame	Description
Oral cancer	the 10 years of the study	Arising of a lesion of oral cancer or a premalignant lesion

Countries

Egypt

Contacts

Primary ContactAyat Gamal-AbdelNaser

ayat.gamal@dentistry.cu.edu.eg01001874257

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026