Influence of High Vitamin C Dose on Lactate During and After Extracorporeal Circulation

Influence of High Vitamin C Dose on Lactate During Extracorporeal Circulation for Heart Surgery and During the 24 Hours Thereafter. (double Blind Prospective Randomised Study)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04046861

Enrollment

Registered

2019-08-06

Start date

2023-03-01

Completion date

2024-09-01

Last updated

2025-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bypass Complication, Cardiac Disease, Hyperlactatemia, Valve Disease, Heart, Vitamin C

Keywords

cardiac surgery, cardiopulmonary bypass, hyperlactatemia, vitamin C

Brief summary

The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.

Interventions

DIETARY_SUPPLEMENTascorbic acid,

The vitamin C group will get high dose of intravenous vitamin C (ascorbic acid) before starting cardiopulmonary bypass, before removing aortic clamp and every 8 hours thereafter for additionaly 24 hours

OTHERPlacebo (saline)

The placebo group will get saline before starting cardiopulmonary bypass, before removing aortic clamp and every 8 hours thereafter for additionaly 24 hours

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* \> 18 years old patients with cardiac disease needing surgery (coronary bypass, valve replacement)

Exclusion criteria

* dementia * kidney stones * dialysis * haemochromatosis * thalassemias * G-6-P deficiency

Design outcomes

Primary

Measure	Time frame	Description
Concentration of lactate	up to 30 hours	Measuring the concentration of lactate before cardiopulmonary bypass, after aortic clamp removal, at ICU admission,then every 6 hours

Secondary

Measure	Time frame	Description
dose of noradrenaline and other vasopressors	up to 36 hours	The need for noradrenaline and other vasopressors (e.g. vasopresin) during the surgery and in the 24-hours after the end of the surgery

Other

Measure	Time frame	Description
Concentration of glucose	up to 30 hours	Measuring the concentration of glucose before cardiopulmonary bypass, after aortic clamp removal, at ICU admission, then every 6 hours

Countries

Slovenia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026