Allergy
Conditions
Brief summary
The researchers are trying to develop an allergy skin test to help predict allergic responses to medications commonly given to patients during surgery.
Detailed description
This study will be a prospective study to accurately determine the negative predictive value of skin testing with NMBAs. It is hypothesized that the concentrations that should be used for NMBAs are actually much lower than previously recommended and that the higher incidence of identifiable NMBA induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).
Interventions
DIAGNOSTIC_TESTSkin Testing
Percutaneous skin prick followed by Intradermal Injections of NMBAs at increasing concentrations compared with an established positive and negative control.
Sponsors
Mayo Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All adults \> or = to 18 y/o undergoing surgery
Exclusion criteria
* Minors under the age of 18 y/o, Adults unable to consent, or those Adults with previous allergic reaction history during previous surgeries.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Non-Irritant Concentrations to common NMBAs | 1 Year | Determine the NIC to common NMBAs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs | 1 Year | Determine Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs |
| Max Concentration used when skin testing to NMBAs | 1 Year | Close gap on the variability of the maximal concentration used when skin testing NMBAs. |
Countries
United States
Outcome results
None listed