Cancer of Esophagus
Conditions
Keywords
impedance, Barrett´s cancer, early detection of cancer
Brief summary
Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment. Early stages of esophageal cancers can be treated by endoscopic resection whereas advanced neoplasia might lead to an Operation of the esophagus. Diagnosis is made usually by biopsies of suspicious lesions or untargeted quadrant biopsies. The electrical properties in inflammatory tissue and cancer can be sensed by electrical bioimpedance technique. The aim of this study is to compare the impedance probe with the histological result and to investigate the feasibility of the new technique in detection of esophageal cancer.
Detailed description
Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment. Early stages of esophageal cancers can be treated by endoscopic resection (ER) whereas advanced neoplasia might lead to esophagectomy. Diagnosis is made usually by biopsies of suspicious lesions or untargeted quadrant biopsies. The electrical properties in inflammatory tissue and dysplasia can be sensed by electrical bioimpedance technique. The aim of this study is to compare the impedance probe with the histological result and to investigate the feasibility of the new technique in detection of esophageal cancer.
Interventions
DEVICEimpedance
After endoscopic resection of early esophageal cancer, the tissue will be measured by an impedance probe between 10Hz-1000000Hz, 20mV. 8 gold electrodes have been integrated to the probe. The impedance will be measured in different ways between the elctrodes. There will be 10 measurements in total for each specimen.
Sponsors
Sana Klinikum Offenbach
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Masking description
no masking
Intervention model description
Observation group: patient who are planned for endoscopic resection because of known esophageal cancer. Immediately after retrieval the resected specimens will be investigated for their electrical impedance properties. The results of the impedance measurement are compared to the histological results.
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
Known esophageal cancer and planned for endoscopic resection
Exclusion criteria
1. Missing consent / agreement 2. Patient in bad condition for endoscopy or endoscopic resection 3. Patients with coagulopathy or anticoagulative medication which is a contraindication for endoscopy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| impedance | 10 min | value of 17 different frequencies in ohm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| differences in impedance | 10 min | Differences in electrical impedance properties between different stages of early esophageal cancer. |
Countries
Germany
Outcome results
None listed