Chronic Obstructive Pulmonary Disease
Conditions
Keywords
meridians, acupuncture, chronic stable angina pectoris, meridian phenomenon, laser doppler
Brief summary
Although some important progresses were made in the field of the meridian research, no breakthroughs have been achieved. Besides,there are some problems in meridian researches. Particularly, previous research of meridian phenomenon involved lots of subjective elements and outcomes.Researches that use modern scientific techniques to investigate the biological characteristics of meridian phenomenon are urgently needed. Therefore, this study is designed to assess the microcirculatory characteristics of meridian phenomenon for the Heart and Lung meridians by using laser doppler. Thus, the biological characteristics of meridian phenomenon could be presented objectively in a scientific methodology
Detailed description
This study will include 40 patients diagnosed with chronic obstructive pulmonary disease (COPD) and 80 healthy volunteers. Laser doppler examination will be adopted to assess the microcirculatory characteristics of meridian phenomenon for Heart and Lung meridians in the physiology/pathological state. Moreover, the site specificity for the meridian-visceral association and surface-surface association between the Heart and Lung meridians will be investigated.Primary outcomes will be blood flow curve and blood perfusion units(PU).Furthermore, this study will build standardized techniques and schemes for detecting the microcirculatory characteristics of meridian phenomenon for Heart and Lung meridians. The results of this study could also provide scientific foundation for traditional meridian theories.
Interventions
DEVICELaser doppler
A laser doppler flowmetry will be used to measure the microcirculatory characteristics of meridian phenomena. The probes will be left at relevant measuring sites. Blood flow curve and Perfusion units (PU ) will be recorded constantly. 1. Healthy control group and COPD group The probes will be left at Shenmen (HT7) and Shaohai (HT3) of the Heart meridian, Taiyuan (LU9) and Chize (LU5) of the Lung meridian for 5 minutes. 2. Healthy intervention group Two sessions of moxibustion will be performed in the Heart meridian and Lung meridian successively.
Sponsors
The Third Affiliated hospital of Zhejiang Chinese Medical University
The First Affiliated Hospital of Zhejiang Chinese Medical University
Zhejiang Chinese Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria for the COPD group 1. Patients should meet the above diagnostic criteria, and the severity of COPD is in the stage of GOLD 2 or 3 based on pulmonary function testing; 2. COPD patients in the stable phase, who present with mild symptoms of cough, expectoration and short breath; 3. 35 ≤ age ≤75 years, male or female; 4. Patients have clear consciousness and could communicate with others normally; 5. Patients could understand the full study protocol and have high adherence.Written informed consent is signed by themselves or their lineal kin. Inclusion criteria for health volunteers 1. Healthy volunteers who could provide a recent (in the past 3 month) medical examination report to confirm they have not any cardiovascular, respiratory, digestive, urinary, hematological, endocrine and neurological disease; 2. age ≥20 years, male or female; 3. Participants have clear consciousness and could communicate with others normally; 4. Participants could understand the full study protocol and have high adherence .Written informed consent is signed by themselves or their lineal kin.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood flow curve | 5 minutes of baseline, 15 minutes during moxibustion and 5 minutes after stopping moxibustion. | The blood flow curve could reflect the microcirculatory flux in the measuring sites. |
| Blood perfusion units | 5 minutes of baseline, 15 minutes during moxibustion and 5 minutes after stopping moxibustion. | Perfusion units (PU)=concentration of moving blood cells (CMBC)×velocity (V) |
Countries
China
Contacts
Primary ContactYongliang Jiang
Backup ContactHantong Hu
Outcome results
None listed