Brain Infarction
Conditions
Brief summary
The investigator retrospectively analyzed consecutive young (\<60 years) cryptogenic stroke patients with Patient Foramen Ovale (PFO) recruited between January 2016 and May 2019 in our center, and compared these patients with sex- and age-matched controls with cryptogenic stroke without PFO. Analyzed baseline characteristics: sex, age, cardiovascular risk factors, history of stroke, and cortical/subcortical localization, arterial territory, number of lesions, and lesion size of the acute symptomatic infarction, together with the ROPE score. The presence and the number of acute and chronic SCCI lesions were assessed.
Interventions
OTHERMRI scanner
MRI was performed with a 1.5T magnet (Ingenia, Philips, The Netherlands; diffusion-weighted imaging b-values = 0 and 1,000 s/mm2, TR 4,280 ms, and TE 97 ms). In case of technical problems with the 1.5T MRI scanner, a 3T magnet (Skyra, Siemens, Erlangen, Germany) was used. MRI was analyzed by an experienced rater (DR), blinded to clinical data and MRI sequences other than diffusion-weighted imaging.
OTHERContrast transoesophageal echocardiography
Contrast transoesophageal echocardiography (including Valsalva manoeuvre)
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* patients : young (\<60 years) adult patients, * Patient recruited and registered in our stroke database between January 2016 and May 2016 of our center (Nîmes University Hospital, France), * Patients presenting with an acute symptomatic infarction (confirmed by diffusion-weighted MRI) of unknown origin * Controls : age-matched controls with cryptogenic stroke without PFO
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| presence of multiterritorial infarction | day 1 | mixed anterior-posterior circulation or bilateral anterior circulation |
| infarction location | day 1 | anterior, posterior, or mixed anterior-posterior circulation and the cortical/subcortical/corticosubcortical location of infarction |
| number of infarction lesions | day 1 | Number (increase) |
| size of subcortical lesion | day 1 | \< or \>15mm |
Countries
France
Outcome results
None listed