Chronic Total Occlusion Registry

A Multicenter, Prospective, Real World Observational Study for Chronic Total Occlusion

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04041921

Acronym

IRIS CTO

Enrollment

4006

Registered

2019-08-01

Start date

2010-01-31

Completion date

2022-04-08

Last updated

2022-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Stenosis, Coronary Occlusion, Coronary Stenosis

Keywords

CTO, PCI, CABG, Medical treatment, Decision CTO

Brief summary

This study evaluated the long-term outcome of patients with chronic total occlusion treated with percutaneous coronary intervention, medical treatment or coronary artery bypass grafting.

Detailed description

This study is connected with Decision-CTO trial(NCT01078051). Randomized subjects and registry group subjects from Decision-CTO trial continue 10 years follow-up on this study.

Interventions

PROCEDUREPercutaneous coronary intervention

PROCEDURECoronary Artery Bypass Grafting

DRUGMedical treatment

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with angina or silent ischemia and documented ischemia * Patients with De novo chronic coronary occlusion ≥ 3months and reference diameter ≥ 2.5 mm on coronary angiography * Age \> 18 years

Exclusion criteria

* Refuse to participate in this study

Design outcomes

Primary

Measure	Time frame
Composite event of all cause death, myocardial infarction, stroke or all kinds of repeat revascularization	10 years

Secondary

Measure	Time frame	Description
Event rate of acute myocardial infarction	10 years	—
Event rate of stroke	10 years	—
Event rate of repeat revascularization	10 years	—
Event rate of all cause death	10 years	—
The rate change of left ventricular ejection fraction	10 years	—
Composite event of death, myocardial, stroke or repeat revascularization	5 years	—
Event rate of Procedural success	5 days	Procedural success is defined as \< 30% final stenosis and the absence of in-hospital event including death, Q-wave myocardial infarction or urgent repeat revascularization.
Event rate of rehospitalization due to acute coronary syndrome	10 years	—

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026