Celiac Disease
Conditions
Keywords
Prevalence, General population, Diagnosis, Prognosis, Etiology, Genes
Brief summary
In this study, all citizen of Nord-Trøndelag County, Norway, above 20 years of age are invited to participate in a population-based health study, the HUNT study. Blood samples are drawn from the participants and assessed for celiac disease by a serological assay. Celiac disease is a chronic inflammatory disease of the small intestine due to dietary gluten in wheat, barley and rye. The diagnosis will be verified through endoscopic assessment and biopsies from the small intestinal mucosa. The aims of the study are 1) to establish the population-based prevalence of celiac disease; 2) to assess the consequences of the disease from patient reported outcomes, symptoms, deficiencies, and co-morbidity; 3) to study possible risk factors and environmental triggering events; 4) to identify genetic predictors and gene-environmental interactions.
Interventions
DIAGNOSTIC_TESTEndoscopy and biopsy
Participants with a positive celiac serology are assessed by endoscopy and duodenal biopsy
Sponsors
University of Oslo
Oslo University Hospital
Helse Nord-Trøndelag HF
University of Groningen
Karolinska Institutet
Norwegian University of Science and Technology
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Intervention model description
All inhabitants of Nord-Trøndelag County, Norway, above 18 years of age are invited to participate
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participants of the forth round of the HUNT study
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of celiac disease | 1 year | the proportion of cases in the general population of Nord-Trøndelag County, Norway |
Countries
Norway
Outcome results
None listed